dipeptide-6
synthetic peptide consisting of proline and hydroxyproline

Supplier Sponsors

• 
  BOC Sciences

  Best of Chemicals Supplier
  Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
  BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
  BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
  Email:	Marketing
  US Email:	Marketing
  Email:	Sales
  US Email:	Sales
  Voice: 1-631-485-4226
  Fax: 1-631-614-7828
  US Voice: 1-631-485-4226
  US Fax: 1-631-614-7828
  Europe	44-203-286-1088
  Facebook
  Twitter
  Linkedin
  Blog
  Get the App!
  CODE172956 CODE172956
  Product(s):
  18684-24-7 Pro-Hyp-OH ≥98% (TLC)

CAS Number: 18684-24-7 3D/inchi FDA UNII: Search Nikkaji Web: J666.108D XlogP3-AA: -3.30 (est) Molecular Weight: 228.24832000 Formula: C10 H16 N2 O4 NMR Predictor: Predict (works with chrome, Edge or firefox) Category:cosmetic ingredient for skin conditioning   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Soluble in:   water, 2.219e+004 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: CosIng: cosmetic data Cosmetic Uses: skin conditioning   Suppliers: BOC Sciences For experimental / research use only. Pro-Hyp-OH ≥98% (TLC)   Safety Information:   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: Not determined Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: cosmetic ingredient for skin conditioning Recommendation for dipeptide-6 usage levels up to:   not for fragrance use.   Recommendation for dipeptide-6 flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry National Institute of Allergy and Infectious Diseases:Data (2S,4R)-4-hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid   References:   (2S,4R)-4-hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid NIST Chemistry WebBook: Search Inchi Pubchem (cid): 11902893 Pubchem (sid): 277409869   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View HMDB (The Human Metabolome Database): HMDB06695 FooDB: FDB024028   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms: (2S,4R)-4- hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid l- proline, L-prolyl-4-hydroxy-, (4R)-   synthetic peptide consisting of proline and hydroxyproline   Articles:   None found yet. Try the PubMed Search.

Notes: Prolylhydroxyproline is a dipeptide. Prolylhydroxyproline is a marker of bone collagen degradation, showing high sensitivity for the diagnosis of osteoporosis. Prolylhydroxyproline has been suggested as a possible alternative to hydroxyproline determination in bone resorption studies. Prolylhydroxyproline is one of the iminodipeptides present in the urine of patients with prolidase deficiency. Prolidase (X-Pro dipeptidase EC 3.4. 13.9) splits iminodipeptides containing C-terminal proline or hydroxyproline (X-Pro or X-Hyp) to X+Pro or X+Hyp. Prolidase deficiency is a rare autosomal recessive disease characterized by chronic ulcerative dermatitis and mental retardation. These patients excrete large amounts of iminodipeptides containing C-terminal proline in the urine due to hereditary prolidase deficiency. (PMID: 12636053, 11863289, 2387877, 1874885, 9586797) [HMDB]