punica granatum seed
seed from the pomegranate, punica granatum l., punicaceae
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Name: punica granatum l. seed
CAS Number: 84961-57-9 
ECHA EC Number: 284-646-0
Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: abrasives
bulking agents
skin conditioning
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Pomegranate Seeds
Noble Molecular Research
For experimental / research use only.
Punica Granatum Seed
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for punica granatum seed usage levels up to:
 not for fragrance use.
Recommendation for punica granatum seed flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
AIDS Citations: Search
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EPA ACToR: Toxicology Data
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National Institute of Allergy and Infectious Diseases: Data
 punica granatum l. seed
Chemidplus: 084961579
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 punica granatum l. seed
Canada Domestic Sub. List: 84961-57-9
Pubchem (sid): 135300670
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 pomegranate seed
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 pomegranate seed
 punica florida seed
 punica grandiflora seed
 punica nana seed
 punica spinosa seed
 seed from the pomegranate, punica granatum l., punicaceae
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PubMed: Comparison of iso-eluotropic mobile phases at different temperatures for the separation of triacylglycerols in Non-Aqueous Reversed Phase Liquid Chromatography.
PubMed: Pomegranate seed hydroalcoholic extract improves memory deficits in ovariectomized rats with permanent cerebral hypoperfusion /ischemia.
PubMed: Evaluation of antioxidant and antiradical properties of Pomegranate (Punica granatum L.) seed and defatted seed extracts.
PubMed: Effects of dietary pomegranate seed pulp on oxidative stability of kid meat.
PubMed: Protective effects of pomegranate seed oil on ovariectomized rats as a model of postmenopausal osteoporosis: A multi-detector computed tomography evaluation.
PubMed: Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed.
PubMed: Osteogenic potential of punica granatum through matrix mineralization, cell cycle progression and runx2 gene expression in primary rat osteoblasts.
PubMed: Protective effect of Punica granatum peel and Vitis vinifera seeds on DEN-induced oxidative stress and hepatocellular damage in rats.
PubMed: Crystal structure of class III chitinase from pomegranate provides the insight into its metal storage capacity.
PubMed: Pomegranate seed oil: Effect on 3-nitropropionic acid-induced neurotoxicity in PC12 cells and elucidation of unsaturated fatty acids composition.
PubMed: Protective effect of pomegranate seed oil against mercuric chloride-induced nephrotoxicity in rat.
PubMed: Punica granatum cv. Dente di Cavallo seed ethanolic extract: antioxidant and antiproliferative activities.
PubMed: An in vitro study reveals the nutraceutical potential of punicic acid relevant to diabetes via enhanced GLUT4 expression and adiponectin secretion.
PubMed: Combined transgenic expression of Punica granatum conjugase (FADX) and FAD2 desaturase in high linoleic acid Arabidopsis thaliana mutant leads to increased accumulation of punicic acid.
PubMed: Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punica granatum L.) seed oil on breast cancer cell lines.
PubMed: Inhibition of the recombinant cattle tick Rhipicephalus (Boophilus) annulatus glutathione S-transferase.
PubMed: Inhibitory effect of a novel combination of Salvia hispanica (chia) seed and Punica granatum (pomegranate) fruit extracts on melanin production.
PubMed: Preventive Effect of Three Pomegranate (Punica granatum L.) Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice.
PubMed: Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD.
PubMed: Effects of pomegranate seed oil on insulin release in rats with type 2 diabetes.
PubMed: Preventive effects of pomegranate seed extract on bleomycin-induced pulmonary fibrosis in rat.
PubMed: Protective effect of pomegranate seed oil against acute toxicity of diazinon in rat kidney.
PubMed: Inhibitory effects of pomegranate seed extract on the formation of heterocyclic aromatic amines in beef and chicken meatballs after cooking by four different methods.
PubMed: An aqueous pomegranate seed extract ameliorates oxidative stress of human hepatoma HepG2 cells.
PubMed: Enrichment of functional properties of ice cream with pomegranate by-products.
PubMed: Improving active and passive avoidance memories deficits due to permanent cerebral ischemia by pomegranate seed extract in female rats.
PubMed: Pomegranate seed oil prevents bone loss in a mice model of osteoporosis, through osteoblastic stimulation, osteoclastic inhibition and decreased inflammatory status.
PubMed: Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats.
PubMed: Pomegranate and type 2 diabetes.
PubMed: Effects of pomegranate seed oil on glucose and lipid metabolism-related organs in rats fed an obesogenic diet.
PubMed: Nutritional protective mechanisms against gut inflammation.
PubMed: Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study.
PubMed: Well-defined inorganic/organic nanocomposite by nano silica core-poly(methyl methacrylate/butylacrylate/trifluoroethyl methacrylate) shell.
PubMed: Pomegranate seed extract attenuates chemotherapy-induced liver damage in an experimental model of rabbits.
PubMed: Improved glycemic control, pancreas protective and hepatoprotective effect by traditional poly-herbal formulation "Qurs Tabasheer" in streptozotocin induced diabetic rats.
PubMed: Medicinal plants used by the Bapedi traditional healers to treat diarrhoea in the Limpopo Province, South Africa.
PubMed: Microencapsulation of conjugated linolenic acid-rich pomegranate seed oil by an emulsion method.
PubMed: Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) seed oil.
PubMed: Identification of seven water-soluble non-storage proteins from pomegranate (Punica granatum Linn.) seeds.
PubMed: Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis.
PubMed: Aldose reductase inhibitory activity and antioxidant capacity of pomegranate extracts.
PubMed: A novel strategy for identification of 47 pomegranate (Punica granatum) cultivars using RAPD markers.
PubMed: Rectal ulcer secondary to a fecal impaction due to pomegranate seed bezoar.
PubMed: Seed extract of Punica granatum possesses antioxidant and antiulcer potential.
PubMed: Modelling moisture diffusivity of pomegranate seed cultivars under fixed, semi fluidized and fluidized bed using mathematical and neural network methods.
PubMed: Antioxidant capacities of phenolic compounds and tocopherols from Tunisian pomegranate (Punica granatum) fruits.
PubMed: Pomegranate seed oil in women with menopausal symptoms: a prospective randomized, placebo-controlled, double-blinded trial.
PubMed: Xanthigen suppresses preadipocyte differentiation and adipogenesis through down-regulation of PPAR╬│ and C/EBPs and modulation of SIRT-1, AMPK, and FoxO pathways.
PubMed: Determination of lignans in edible and nonedible parts of pomegranate (Punica granatum L.) and products derived therefrom, particularly focusing on the quantitation of isolariciresinol using HPLC-DAD-ESI/MSn.
PubMed: Effect of pomegranate seed oil on serum TNF-╬▒ level in dyslipidemic patients.
PubMed: The effect of salt, extract of kinnow and pomegranate fruit by-products on colour and oxidative stability of raw chicken patties during refrigerated storage.
PubMed: Chitinase III in pomegranate seeds (Punica granatum Linn.): a high-capacity calcium-binding protein in amyloplasts.
PubMed: Short communication: effects of supplementation with pomegranate seed pulp on concentrations of conjugated linoleic acid and punicic acid in goat milk.
PubMed: Total phenolic distribution of juice, peel, and seed extracts of four pomegranate cultivars.
PubMed: Genetic diversity of Iranian soft-seed pomegranate genotypes as revealed by fluorescent-AFLP markers.
PubMed: A pomegranate (Punica granatum L.) WD40-repeat gene is a functional homologue of Arabidopsis TTG1 and is involved in the regulation of anthocyanin biosynthesis during pomegranate fruit development.
PubMed: Pomegranate seed extract attenuates chemotherapy-induced acute nephrotoxicity and hepatotoxicity in rats.
PubMed: Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice.
PubMed: Differential attraction of Aedes albopictus in the field to flowers, fruits and honeydew.
PubMed: Tenderizing effect of blade tenderizer and pomegranate fruit products in goat meat.
PubMed: Screening of certain medicinal plants from India for their anti-quorum sensing activity.
PubMed: Fatty acids from Tunisian and Chinese pomegranate (Punica granatum L.) seeds.
PubMed: Growth inhibitory, antiandrogenic, and pro-apoptotic effects of punicic acid in LNCaP human prostate cancer cells.
PubMed: Characterization of a potential nutraceutical ingredient: pomegranate (Punica granatum L.) seed oil unsaponifiable fraction.
PubMed: Protective effect of pomegranate seed oil on hexachlorobutadiene-induced nephrotoxicity in rat kidneys.
PubMed: Extract of Punica granatum inhibits skin photoaging induced by UVB irradiation.
PubMed: Effect of salt, kinnow and pomegranate fruit by-product powders on color and oxidative stability of raw ground goat meat during refrigerated storage.
PubMed: Anti-oxidant effect of extracts of kinnow rind, pomegranate rind and seed powders in cooked goat meat patties.
PubMed: Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial.
PubMed: Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity.
PubMed: Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferation.
PubMed: Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats.
PubMed: The effects of pomegranate seed extract and beta-sitosterol on rat uterine contractions.
PubMed: The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat.
PubMed: Antioxidant capacity and lipid characterization of six Georgia-grown pomegranate cultivars.
PubMed: Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats.
PubMed: Toxicological evaluation of pomegranate seed oil.
PubMed: Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice.
PubMed: Effect of cold stratification treatments on germination of drought tolerant shrubs seeds.
PubMed: Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats.
PubMed: Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer.
PubMed: Inhibition of aflatoxin B production of Aspergillus flavus, isolated from soybean seeds by certain natural plant products.
PubMed: Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid.
PubMed: Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice.
PubMed: Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells.
PubMed: Alpha-linolenic acid but not conjugated linolenic acid is hypocholesterolaemic in hamsters.
PubMed: The Effect of Two Methods of Pomegranate (Punica granatum L) Juice Extraction on Quality During Storage at $4^\circ$ C.
PubMed: Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture.
PubMed: Dietary effect of pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic OLETF rats.
PubMed: Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions.
PubMed: Antioxidant activity of plant extracts on the inhibition of citral off-odor formation.
PubMed: Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats.
PubMed: Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo.
PubMed: Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry.
PubMed: Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice.
PubMed: Delta 12-oleate desaturase-related enzymes associated with formation of conjugated trans-delta 11, cis-delta 13 double bonds.
PubMed: Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer.
PubMed: Monoacylglycerol from Punica granatum seed oil.
PubMed: Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models.
PubMed: Studies on the hypoglycaemic activity of Punica granatum seed in streptozotocin induced diabetic rats.
PubMed: Studies on antidiarrhoeal activity of Punica granatum seed extract in rats.
PubMed: Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids.
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