EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

podophyllum emodi resin
podophyllin

Supplier Sponsors

CAS Number: 9000-55-9
Other(deleted CASRN):8050-60-0
ECHA EC Number:232-546-2
FDA UNII: 16902YVY2B
MDL:MFCD00131926
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Podophyllin from Podophyllum emodii 95%
ExtraSynthese
For experimental / research use only.
Podophyllin
Nanda Medicinal Plants
Podophyllum Emodi W /p
Penta International
PODOPHYLLUM RESIN USP
Santa Cruz Biotechnology
For experimental / research use only.
Podophyllin
Sigma-Aldrich: Sigma
For experimental / research use only.
Podophyllin from Podophyllum emodii powder
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
unreported-dog LDLo 120 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

oral-man LDLo 157 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING
Southern Medical Journal. Vol. 75, Pg. 1269, 1982.

oral-man TDLo 1333 mg/kg
BEHAVIORAL: COMA
Human Toxicology. Vol. 1, Pg. 373, 1982.

oral-mouse LD50 68 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT
Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.

intraperitoneal-rat LD50 15 mg/kg
Proceedings of the Society for Experimental Biology and Medicine. Vol. 113, Pg. 124, 1963.

parenteral-rat LD50 25 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 84, Pg. 68, 1950.

Dermal Toxicity:
subcutaneous-mouse LD50 58 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.

subcutaneous-rat LD50 18 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: EXCITEMENT
Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for podophyllum emodi resin usage levels up to:
 not for fragrance use.
 
Recommendation for podophyllum emodi resin flavor usage levels up to:
 not for flavor use.
 
Safety References:
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0009000559
RTECS:TP8925000 for cas# 9000-55-9
 
References:
Pubchem (sid):135356078
 
Other Information:
MedlinePlusSupp:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 podophyllum emodi
Search Trop Picture
 
Synonyms:
 podophyllin
 podophyllum hexandrum resin
 podophyllum resin USP
 
 
Notes:
caustic extract from the roots of podophyllum peltatum and p. emodi. it contains podophyllotoxin and its congeners and is very irritating to mucous membranes and skin. podophyllin is a violent purgative that may cause cns damage and teratogenesis. it is used as a paint for warts, skin neoplasms, and senile keratoses.
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy