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valerian rhizome/root
plant material derived from the dried rhizomes and roots of the valerian, valeriana officinalis l., valerianaceae

Supplier Sponsors

Name:	valeriana officinalis l. rhizome/root
CAS Number:	8057-49-6
ECHA EC Number:	232-501-7
FDA UNII:	Search

Category:soothing agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
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Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Food Chemicals Codex Listed:

No

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	soothing agents

Suppliers:

Bristol Botanicals

Valerian root powder Valeriana officinalis

Bristol Botanicals

Valerian root Valeriana officinalis

Pride International

Qingdao Dacon Trading

Valerian Root Powder

Qingdao Dacon Trading

valerian Bulgaria organic

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mammal (species unspecified) LD50 975 mg/kg Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988. oral-mammal (species unspecified) LD50 2250 mg/kg Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988. intraperitoneal-mouse LD50 3300 mg/kg KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED Journal of Pharmaceutical Sciences. Vol. 50, Pg. 240, 1961.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
soothing agents
Recommendation for valerian rhizome/root usage levels up to:
	not for fragrance use.

Recommendation for valerian rhizome/root flavor usage levels up to:
	not for flavor use.

Safety References:

ClinicalTrials.gov:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

valeriana officinalis l. rhizome/root

Chemidplus:0008057496

References:

	valeriana officinalis l. rhizome/root
Pubchem (sid):	135331255

Other Information:

Wikipedia:

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

valerian
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Synonyms:

	plant material derived from the dried rhizomes and roots of the valerian, valeriana officinalis l., valerianaceae
	valerian bulgaria organic
	valerian rhizome/root
	valeriana officinalis rhizome/root

Articles:

PubMed:Plant hairy root cultures as plasmodium modulators of the slime mold emergent computing substrate Physarum polycephalum.

PubMed:Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish).

PubMed:Valeriana officinalis Extracts Ameliorate Neuronal Damage by Suppressing Lipid Peroxidation in the Gerbil Hippocampus Following Transient Cerebral Ischemia.

PubMed:Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites.

PubMed:The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model.

PubMed:Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial.

PubMed:Valerian: no evidence for clinically relevant interactions.

PubMed:Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway.

PubMed:Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation.

PubMed:Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis.

PubMed:Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis).

PubMed:Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study.

PubMed:Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.

PubMed:Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.

PubMed:Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine.

PubMed:Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.

PubMed:Root colonization by symbiotic arbuscular mycorrhizal fungi increases sesquiterpenic acid concentrations in Valeriana officinalis L.

PubMed:Pinoresinol-4,4'-di-O-beta-D-glucoside from Valeriana officinalis root stimulates calcium mobilization and chemotactic migration of mouse embryo fibroblasts.

PubMed:Determination of metal content in valerian root phytopharmaceutical derivatives by atomic spectrometry.

PubMed:In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4.

PubMed:Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans.

PubMed:Analysis of responses to valerian root extract in the feline pulmonary vascular bed.

PubMed:(-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis.

PubMed:[Clinical studies on the treatment of coronary heart disease with Valeriana officinalis var latifolia].

PubMed:Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier.

PubMed:High-yield production of valepotriates by hairy root cultures of Valeriana officnalis L. var. sambucifolia Mikan.

PubMed:Valepotriate content in different in vitro cultures of Valerianaceae and characterization of Valeriana officinalis L. callus during a growth period.

PubMed:Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man.

PubMed:[Biological titration of the root of Valeriana officinalis].

Notes:

None found

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