| PubMed:Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells. |
| PubMed:Oxidative stress and production of bioactive monoterpene indole alkaloids: biotechnological implications. |
| PubMed:Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production. |
| PubMed:Plant extracts for the topical management of psoriasis: a systematic review and meta-analysis. |
| PubMed:Characterization and quantification of 10-hydroxycamptothecine in Camptotheca acuminate and its medicinal preparation by liquid chromatography-ion trap mass spectrometry. |
| PubMed:New and highly efficient column chromatographic extraction and simple purification of camptothecin from Camptotheca acuminata and Nothapodytes pittosporoides. |
| PubMed:Isolation and characterization of endophytic fungi from Camptotheca acuminata. |
| PubMed:Blastococcus endophyticus sp. nov., an actinobacterium isolated from Camptotheca acuminata. |
| PubMed:Development of transcriptomic resources for interrogating the biosynthesis of monoterpene indole alkaloids in medicinal plant species. |
| PubMed:Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. |
| PubMed:The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK. |
| PubMed:Anticancer drugs from traditional toxic Chinese medicines. |
| PubMed:Camptothecin fails to induce apoptosis in tumor necrosis factor-alpha-treated HaCaT cells. |
| PubMed:Delivery methods of camptothecin and its hydrosoluble analogue irinotecan for treatment of colorectal cancer. |
| PubMed:Medicinal plants: a public resource for metabolomics and hypothesis development. |
| PubMed:Plantactinospora endophytica sp. nov., an actinomycete isolated from Camptotheca acuminata Decne., reclassification of Actinaurispora siamensis as Plantactinospora siamensis comb. nov. and emended descriptions of the genus Plantactinospora and Plantactinospora mayteni. |
| PubMed:Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport. |
| PubMed:Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and cell culture, and the affected yields under several cell culture treatments. |
| PubMed:Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis. |
| PubMed:Nitrate reductase-mediated nitric oxide generation is essential for fungal elicitor-induced camptothecin accumulation of Camptotheca acuminata suspension cell cultures. |
| PubMed:Correlations between camptothecin and related metabolites in Camptotheca acuminata reveal similar biosynthetic principles and in planta synergistic effects. |
| PubMed:Correlation of camptothecin-producing ability and phylogenetic relationship in the genus Ophiorrhiza. |
| PubMed:Evaluation of antimicrobial activity of endophytic fungi from Camptotheca acuminata (Nyssaceae). |
| PubMed:Rhizobium kunmingense sp. nov., isolated from rhizosphere soil of Camptotheca acuminata Decne. |
| PubMed:Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae). |
| PubMed:10-Hydroxycamptothecin produced by a new endophytic Xylaria sp., M20, from Camptotheca acuminata. |
| PubMed:Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza species. |
| PubMed:Metabolite fingerprinting of Camptotheca acuminata and the HPLC-ESI-MS/MS analysis of camptothecin and related alkaloids. |
| PubMed:Novel camptothecin derivatives as topoisomerase I inhibitors. |
| PubMed:[Isolation and purification of 10-hydroxycamptothecin and vincoside-lactam from Camptotheca acuminata seed by polyamide]. |
| PubMed:An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues. |
| PubMed:Allene oxide cyclase from Camptotheca acuminata improves tolerance against low temperature and salt stress in tobacco and bacteria. |
| PubMed:Molecular cloning, characterization and expression of a jasmonate biosynthetic pathway gene encoding allene oxide cyclase from Camptotheca acuminata. |
| PubMed:[Effects of nitrogen forms on camptothecin content and its metabolism-related enzymes activities in Camptotheca acuminata seedlings]. |
| PubMed:[The study of dynamic acccumulation of camptothecin in Camptotheca acuminata fruit by TLCS]. |
| PubMed:Micropropagation and production of Camptothecin from in vitro plants of Ophiorrhiza rugosa var. decumbens. |
| PubMed:[Effect of nitrogen on camptothecin content in Camptotheca acuminata seedlings]. |
| PubMed:Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants. |
| PubMed:Molecular cloning and characterization of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (CaHDR) from Camptotheca acuminata and its functional identification in Escherichia coli. |
| PubMed:A new isopentenyl diphosphate isomerase gene from Camptotheca acuminata: cloning, characterization and functional expression in Escherichia coli. |
| PubMed:Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies. |
| PubMed:CPT accumulation in the fruit and during early phases of plant development in Camptotheca acuminata Decaisne (Nyssaceae). |
| PubMed:[Callus induction and cultivation of Camptotheca acuminata]. |
| PubMed:Camptothecin: therapeutic potential and biotechnology. |
| PubMed:Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine. |
| PubMed:Characteristics of the microbial community in rhizosphere of Camptotheca acuminata cultured with exotic invasive plant Eupatorium adenophorum. |
| PubMed:Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata. |
| PubMed:Extraction and composition of three naturally occurring anti-cancer alkaloids in Camptotheca acuminata seed and leaf extracts. |
| PubMed:[Effects of cu2+ on biosynthesis of camptothecin in cell cultures of Camptotheca acuminata]. |
| PubMed:Triterpenoids and ellagic acid derivatives from in vitro cultures of Camptotheca acuminata Decaisne. |
| PubMed:Total synthesis and biological evaluation of 22-hydroxyacuminatine. |
| PubMed:Molecular cloning and characterization of a novel stem-specific gene from Camptotheca acuminata. |
| PubMed:Concise synthesis of 22-hydroxyacuminatine, cytotoxic camptothecinoid from Camptotheca acuminata, by pyridone benzannulation. |
| PubMed:Laticifers in Camptotheca acuminata Decne: distribution and structure. |
| PubMed:Wound-induced expression of the ferulate 5-hydroxylase gene in Camptotheca acuminata. |
| PubMed:An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes. |
| PubMed:Camptothecin and its analogues: a review on their chemotherapeutic potential. |
| PubMed:The effect of growth regulators and sucrose on anthocyanin production in Camptotheca acuminata cell cultures. |
| PubMed:Molecular characterization of two anthranilate synthase alpha subunit genes in Camptotheca acuminata. |
| PubMed:New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminata. |
| PubMed:Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminata. |
| PubMed:[Accumulation and localization of camptothecin in young shoot of Camptotheca acuminata]. |
| PubMed:Improvement of growth and camptothecin yield by altering nitrogen source supply in cell suspension cultures of Camptotheca acuminata. |
| PubMed:Cellular localisation of the anti-cancer drug camptothecin in Camptotheca acuminata Decne (Nyssaceae). |
| PubMed:Camptothecin, over four decades of surprising findings. |
| PubMed:Rubitecan: 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000. |
| PubMed:Pharmacology of irinotecan. |
| PubMed:Camptothecin and taxol: historic achievements in natural products research. |
| PubMed:Current treatment and future directions in neuroblastoma. |
| PubMed:[Improved camptothecin production by cell lines of Camptotheca acuminata]. |
| PubMed:Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots. |
| PubMed:[Topotecan for pediatric patients with resistant and recurrent solid tumors]. |
| PubMed:The emerging role of irinotecan (CPT-11) in the treatment of malignant glioma in brain tumors. |
| PubMed:Variations in the secondary metabolite camptothecin in relation to tissue age and season in Camptotheca acuminata. |
| PubMed:Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants. |
| PubMed:Bcmfs1, a novel major facilitator superfamily transporter from Botrytis cinerea, provides tolerance towards the natural toxic compounds camptothecin and cercosporin and towards fungicides. |
| PubMed:Advances in cancer therapy with plant based natural products. |
| PubMed:Rapid micro-assay of camptothecin in Camptotheca acuminata. |
| PubMed:Cisplatin and irinotecan in upper gastrointestinal malignancies. |
| PubMed:Therapeutic applications of medicinal plants in the treatment of breast cancer: a review of their pharmacology, efficacy and tolerability. |
| PubMed:Anti-cancer drug discovery and development in Brazil: targeted plant collection as a rational strategy to acquire candidate anti-cancer compounds. |
| PubMed:Apoptosis induction and cell cycle perturbation in human hepatoma hep G2 cells by 10-hydroxycamptothecin. |
| PubMed:[Irinotecan (topoisomerase-I inhibitor) for the treatment of recurrent primary intracranial malignant lymphoma]. |
| PubMed:Cloning of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from terpenoid antibiotic-producing Streptomyces strains. |
| PubMed:Tissue-specific expression of the beta-subunit of tryptophan synthase in Camptotheca acuminata, an indole alkaloid-producing plant. |
| PubMed:The clinical pharmacology of topoisomerase I inhibitors. |
| PubMed:Camptothecin and taxol: discovery to clinic. |
| PubMed:Preclinical pharmacology of the natural product anticancer agent 10-hydroxycamptothecin, an inhibitor of topoisomerase I. |
| PubMed:Topoisomerase I inhibitors: review and update. |
| PubMed:Molecular characterization of three differentially expressed members of the Camptotheca acuminata 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) gene family. |
| PubMed:Antitumor activity and pharmacokinetics following oral administration of natural product DNA topoisomerase I inhibitors 10-hydroxycamptothecin and camptothecin in SCID mice bearing human breast cancer xenografts. |
| PubMed:Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress. |
| PubMed:Sustained harvest of camptothecin from the leaves of Camptotheca acuminata. |
| PubMed:Regression of human colon cancer xenografts in SCID mice following oral administration of water-insoluble camptothecins. |
| PubMed:[Determination of camptothecine in the fruit of Camptotheca acuminata Decne. by RP-HPLC]. |
| PubMed:Cloning and expression of a plant homologue of the small subunit of the Golgi-associated clathrin assembly protein AP19 from Camptotheca acuminata. |
| PubMed:Reversed-phase high-performance liquid chromatography method for the simultaneous quantitation of the lactone and carboxylate forms of the novel natural product anticancer agent 10-hydroxycamptothecin in biological fluids and tissues. |
| PubMed:[Camptothecin and derivatives: a new class of antitumor agents]. |
| PubMed:Camptothecin and taxol: from discovery to clinic. |
| PubMed:Stimulation of interleukin-1beta-converting enzyme activity during growth inhibition by CPT-11 in the human myeloid leukemia cell line K562. |
| PubMed:Preclinical evaluation of CPT-11 and its active metabolite SN-38. |
| PubMed:Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites. |
| PubMed:Camptothecin analogues in the treatment of non-small cell lung cancer. |
| PubMed:Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture. |
| PubMed:Sites of accumulation of the antitumor alkaloid camptothecin in Camptotheca acuminata. |
| PubMed:Inhibition of phosphorylation of histone H1 and H3 induced by 10-hydroxycamptothecin, DNA topoisomerase I inhibitor, in murine ascites hepatoma cells. |
| PubMed:Expression of a 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Camptotheca acuminata is differentially regulated by wounding and methyl jasmonate. |
| PubMed:[Effects of 10-hydroxycamptothecin on induced chromosome aberrations in Chinese hamster ovary cells and micronuclei in mouse bone marrow and fetal liver]. |
| PubMed:DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells. |
| PubMed:Tannins of cornaceous plants. I. Cornusiins A, B and C, dimeric monomeric and trimeric hydrolyzable tannins from Cornus officinalis, and orientation of valoneoyl group in related tannins. |
| PubMed:Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I. |
| PubMed:Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity. |
| PubMed:The effect of hydroxycamptothecin in the activity of RNA and DNA polymerases prepared from murine hepatoma cells. |
| PubMed:Medicinal plants--old and new. |