EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

hypericum perforatum
st. johns wort

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CAS Number: 68917-49-7
FDA UNII: OZU2FC70HY
Category:spices, other natural seasonings and flavorings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FDA Mainterm (SATF):977092-96-8 ; ST. JOHNSWORT LEAVES, FLOWERS AND CAULIS (HYPERICUM PERFORATUM L.)
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.510 Natural flavoring substances and natural substances used in conjunction with flavors.
 
Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Bristol Botanicals
St Johns Wort powder Hypericum perforatum
Bristol Botanicals
St Johnswort Hypericum perforatum
Mountain Valley Growers
Hypericum perforatum St. John's Wort
Nanda Medicinal Plants
Hypericum perforatum Herb
Rose Office
St. John's Wort Bulgaria organic
Vege Tech
O.C. St. John'sWort
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
spices, other natural seasonings and flavorings
Recommendation for hypericum perforatum usage levels up to:
 not for fragrance use.
 
Recommendation for hypericum perforatum flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):68917-49-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
hypericum perforatum l.
Chemidplus:0068917497
 
References:
 hypericum perforatum l.
Canada Domestic Sub. List:68917-49-7
Pubchem (sid):135293306
 
Other Information:
FDA Substances Added to Food (formerly EAFUS):View
FDA Listing of Food Additive Status:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 st. john's wort
Search Trop Picture
 
Synonyms:
 saint john's wort
 saint johns wort
 st johns wort
 st. john's wort
 st. john's wort bulgaria organic
 st. johns wort
 st. johnswort
common st. johnswort
 

Articles:

PubMed:Pilot-scale culture of hypericum perforatum L. Adventitious roots in airlift bioreactors for the production of bioactive compounds.
PubMed:Molecularly imprinted polymer for specific extraction of hypericin from Hypericum perforatum L. herbal extract.
PubMed:Effect of St. John's Wort (Hypericum perforatum) on obesity, lipid metabolism and uterine epithelial proliferation in ovariectomized rats.
PubMed:Immunity: plants as effective mediators.
PubMed:Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum.
PubMed:The immuno-regulatory impact of orally-administered Hypericum perforatum extract on Balb/C mice inoculated with H1n1 influenza A virus.
PubMed:Enhancement of skin radical scavenging activity and stratum corneum lipids after the application of a hyperforin-rich cream.
PubMed:Assessment of antimicrobial and antiprotozoal activity of the olive oil macerate samples of Hypericum perforatum and their LC-DAD-MS analyses.
PubMed:Water extracts of tree Hypericum sps. protect DNA from oxidative and alkylating damage and enhance DNA repair in colon cells.
PubMed:Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats.
PubMed:Effect of hydroalcoholic extract of Hypericum perforatum on selected traditional and novel biochemical factors of cardiovascular diseases and atherosclerotic lesions in hypercholesterolemic rabbits: A comparison between the extract and lovastatin.
PubMed:Effect of hydroalcoholic extract of Hypericum perforatum L. leaves on ethylene glycol-induced kidney calculi in rats.
PubMed:Between species diversity of Hypericum perforatum and H. maculatum by the content of bioactive compounds.
PubMed:Identification and treatment of depression in minority populations.
PubMed:Isolation of Cronobacter sakazakii from different herbal teas.
PubMed:Depression in children and adolescents.
PubMed:History and therapeutic properties of Hypericum Perforatum from antiquity until today.
PubMed:Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages.
PubMed:The quality of information on websites selling St. John's wort.
PubMed:Bioactive xanthones from the roots of Hypericum perforatum (common St John's wort).
PubMed:Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex.
PubMed:Effect of St. John's Wort standardized extract and hypericin on in vitro placental calcium transport.
PubMed:LC-MS/MS multi-analyte method for mycotoxin determination in food supplements.
PubMed:Protective effects of a flavonoid-rich extract of Hypericum perforatum L. against hydrogen peroxide-induced apoptosis in PC12 cells.
PubMed:Depression in children and adolescents.
PubMed:Identification of human intracellular targets of the medicinal Herb St. John's Wort by chemical-genetic profiling in yeast.
PubMed:Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.
PubMed:Pharmacovigilance: effects of herbal components on human drugs interactions involving cytochrome P450.
PubMed:Interactions of food and dietary supplements with drug metabolising cytochrome P450 enzymes.
PubMed:Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells.
PubMed:Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens.
PubMed:Determination of heavy metals for the quality control in Argentinian herbal medicines by ETAAS and ICP-OES.
PubMed:Herbal medicine: the science of the art.
PubMed:Evaluation of the light-sensitive cytotoxicity of Hypericum perforatum extracts, fractions, and pure compounds.
PubMed:Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L.
PubMed:Approach to novel functional foods for stress control 5. Antioxidant activity profiles of antidepressant herbs and their active components.
PubMed:Development of pregnancy in rats treated with Hypericum perforatum.
PubMed:Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats.
PubMed:[Evaluation of Hypericum perforatum toxicity when administered to pregnant rats].
PubMed:Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring rats.
PubMed:Hypocholesterolemic effects of a flavonoid-rich extract of Hypericum perforatum L. in rats fed a cholesterol-rich diet.
PubMed:Usefulness of studies on the molecular mechanism of action of herbals/botanicals: The case of St. John's wort.
PubMed:Herbal drug quality and phytochemical composition of Hypericum perforatum L. affected by ash yellows phytoplasma infection.
PubMed:The significance of "nonsignificance" in randomized controlled studies: a discussion inspired by a double-blinded study on St. John's wort (Hypericum perforatum L.) for premenstrual symptoms.
PubMed:Fast screening method for the analysis of total flavonoid content in plants and foodstuffs by high-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry with polarity switching.
PubMed:Instability of St. John's wort (Hypericum perforatum L.) and degradation of hyperforin in aqueous solutions and functional beverage.
PubMed:Herb-drug interactions: focus on pharmacokinetics.
PubMed:Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro.
PubMed:St. John's Wort (Hypericum perforatum) induces overexpression of multidrug resistance protein 2 (MRP2) in rats: a 30-day ingestion study.
PubMed:In vitro metabolism of hyperforin in rat liver microsomal systems.
PubMed:Hypericum perforatum CO2 extract and opioid receptor antagonists act synergistically to reduce ethanol intake in alcohol-preferring rats.
PubMed:Plant derivatives in the treatment of alcohol dependency.
PubMed:Lopinavir/ritonavir: a review of its use in the management of HIV infection.
PubMed:Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.
PubMed:Determination of St. John's wort components in dietary supplements and functional foods by liquid chromatography.
PubMed:Blockade of gamma-aminobutyric acid receptors does not modify the inhibiton of ethanol intake induced by Hypericum perforatum in rats.
PubMed:Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection.
PubMed:Supercritical fluid extraction and high-performance liquid chromatographic determination of phloroglucinols in St. John's Wort (Hypericum perforatum L.).
PubMed:Antioxidant activity and phenolic compounds in selected herbs.
PubMed:Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats.
PubMed:Optimization of Extraction Conditions for Active Components in Hypericum perforatum Using Response Surface Methodology.
PubMed:Optimization of extraction conditions for active components in Hypericum perforatum using response surface methodology.
PubMed:Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum).
PubMed:Effects of Hypericum perforatum extraction on alcohol intake in Marchigian Sardinian alcohol-preferring rats.
 
Notes:
genus of perennial plants in the family clusiaceae (sometimes classified as hypericaceae). herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. hypericum contains flavonoids; glycosides; mucilage, tannins; volatile oils ( oils, essential), hypericin and hyperforin. tsca definition 2008: extractives and their physically modified derivatives. hypericum perforatum, guttiferae.
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