oregano leaf
lippia graveolens leaf
None found
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Name: lippia graveolens leaf
FDA internal no.: 977138-70-7 
Category: spices, other natural seasonings and flavorings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FEMA Number: 2827  oregano leaf
FDA Regulation:
Subpart B--Specific Food Labeling Requirements
Sec. 101.22 Foods; labeling of spices, flavorings, colorings and chemical preservatives.

Subpart A--General Provisions
Sec. 182.10 Spices and other natural seasonings and flavorings.
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
Odor Type: herbal
Odor Strength: medium
Odor Description:
at 100.00 %. 
Taste Description:
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Cosmetic Information:
None found
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American Natural & Organic Spices
Oregano Ground
Doug Jeffords Company
Oregano, Ground or Leaf
Elite Spice
Oregano – Mediterranean
Elite Spice
Oregano – Mexican
Fuchs North America
Mountain Valley Growers
Lippia graveolens Mexican Oregano
SupHerb Farms
Oregano Medium
Fresh Frozen
SupHerb Farms
Oregano Small
Fresh Frozen
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: spices, other natural seasonings and flavorings
Recommendation for oregano leaf usage levels up to:
 not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -40.00000
beverages(nonalcoholic): -320.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -2800.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -540.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 lippia graveolens leaf
Chemidplus: 0977138707
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 lippia graveolens leaf
Pubchem (sid): 135304026
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Other Information:
FDA Everything Added to Food in the United States (EAFUS): View
Wikipedia: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 lippia graveolens
Search Trop  Picture
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 lippia graveolens leaf
 oregano ground
 oregano medium
 oregano mexico
 oregano small
 sage mexico
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PubMed: Empirical prediction and validation of antibacterial inhibitory effects of various plant essential oils on common pathogenic bacteria.
PubMed: Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity.
PubMed: Effect of the ultrasound-assisted preliminary maceration on the efficiency of the essential oil distillation from selected herbal raw materials.
PubMed: Antimicrobial activity of essential oils of Thymus vulgaris and Origanum vulgare on phytopathogenic strains isolated from soybean.
PubMed: Composition and antiproliferative effect of essential oil of Origanum vulgare against tumor cell lines.
PubMed: Egyptian herbal tea infusions' antioxidants and their antiproliferative and cytotoxic activities against cancer cells.
PubMed: An ethnobotanical study of medicinal plants in high mountainous region of Chail valley (District Swat- Pakistan).
PubMed: Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments.
PubMed: Wound healing activity of Origanum vulgare engineered titanium dioxide nanoparticles in Wistar Albino rats.
PubMed: Effects of herbal essential oil mixture as a dietary supplement on egg production in quail.
PubMed: Sensitive and selective determination of phenolic compounds from aromatic plants using an electrochemical detection coupled with HPLC method.
PubMed: Physiological conjunction of allelochemicals and desert plants.
PubMed: Prediction of essential oil content of oregano by hand-held and Fourier transform NIR spectroscopy.
PubMed: Comparative efficacy of Zataria multiflora Boiss., Origanum compactum and Eugenia caryophyllus essential oils against E. coli O157:H7, feline calicivirus and endogenous microbiota in commercial baby-leaf salads.
PubMed: Metal translocation patterns in Solanum melongena grown in close proximity to traffic.
PubMed: Identification, characterization, and palynology of high-valued medicinal plants.
PubMed: Spectroscopy, microscopy and fluorescence imaging of Origanum vulgare L. basis for nondestructive quality assessment.
PubMed: Evaluation of the leishmanicidal and cytotoxic potential of essential oils derived from ten colombian plants.
PubMed: Lethal and sublethal effects of four essential oils on the egg parasitoids Trissolcus basalis.
PubMed: Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods.
PubMed: Transfer of terpenes from essential oils into cow milk.
PubMed: Congruence of phytochemical and morphological profiles along an altitudinal gradient in Origanum vulgare ssp. vulgare from Venetian Region (NE Italy).
PubMed: Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity.
PubMed: Antimicrobial activity of oregano oil against antibiotic-resistant Salmonella enterica on organic leafy greens at varying exposure times and storage temperatures.
PubMed: Micropropagation effect on the anti-carcinogenic activitiy of polyphenolics from Mexican oregano (Poliomintha glabrescens Gray) in human colon cancer cells HT-29.
PubMed: The radioprotective effects of Origanum vulgare extract against genotoxicity induced by (131)I in human blood lymphocyte.
PubMed: Effect of Phytogenic Feed Additives in Soybean Meal on In vitro Swine Fermentation for Odor Reduction and Bacterial Community Comparison.
PubMed: Decontamination of Salmonella, Shigella, and Escherichia coli O157:H7 from leafy green vegetables using edible plant extracts.
PubMed: Bactericidal activities of health-promoting, food-derived powders against the foodborne pathogens Escherichia coli, Listeria monocytogenes, Salmonella enterica, and Staphylococcus aureus.
PubMed: Effect of Origanum vulgare L. leaves on rumen fermentation, production, and milk fatty acid composition in lactating dairy cows.
PubMed: Traffic-related trace element fate and uptake by plants cultivated in roadside soils in Toronto, Canada.
PubMed: Preventive effects of Egyptian sweet marjoram (Origanum majorana L.) leaves on haematological changes and cardiotoxicity in isoproterenol-treated albino rats.
PubMed: In Vitro efficacy of antimicrobial extracts against the atypical ruminant pathogen Mycoplasma mycoides subsp. capri.
PubMed: Chemical composition and repellency of essential oils from four medicinal plants against Ixodes ricinus nymphs (Acari: Ixodidae).
PubMed: Effects of dietary supplementation with a herbal extract on the performance of broilers infected with a mixture of Eimeria species.
PubMed: Hepatoprotective effect of Origanum vulgare in Wistar rats against carbon tetrachloride-induced hepatotoxicity.
PubMed: Antimicrobial activity of oregano oil on iceberg lettuce with different attachment conditions.
PubMed: Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line.
PubMed: Bacterial Community Dynamics during Swine In vitro Fermentation Using Starch as a Substrate with Different Feed Additives for Odor Reduction.
PubMed: Are leaf glandular trichomes of oregano hospitable habitats for bacterial growth?
PubMed: Effects of cinnamon leaf, oregano and sweet orange essential oils on fermentation and aerobic stability of barley silage.
PubMed: Egyptian sweet marjoram leaves protect against genotoxicity, immunosuppression and other complications induced by cyclophosphamide in albino rats.
PubMed: Chitosan oligosaccharides promote the content of polyphenols in Greek oregano (Origanum vulgare ssp. hirtum).
PubMed: Selective extraction of oxygenated compounds from oregano with sub-critical water.
PubMed: Rumen fermentation and production effects of Origanum vulgare L. leaves in lactating dairy cows.
PubMed: Antibacterial activity and GC/MS analysis of the essential oils from flower, leaf and stem of Origanum vulgare ssp. viride growing wild in north-west Iran.
PubMed: Folk medicine in the northern coast of Colombia: an overview.
PubMed: Studies on antimicrobial activities of solvent extracts of different spices.
PubMed: Acaricidal effect of essential oils from Lippia graveolens (Lamiales: Verbenaceae), Rosmarinus officinalis (Lamiales: Lamiaceae), and Allium sativum (Liliales: Liliaceae) against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).
PubMed: Salt effects on Origanum majorana fatty acid and essential oil composition.
PubMed: Toxicity of ethanolic extracts from Lippia origanoides and Gliricidia sepium to Tetranychus cinnabarinus (Boisduval) (Acari: Tetranychidae).
PubMed: Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger.
PubMed: Antioxidant capacity and total phenolic contents of oregano (Origanum vulgare), lavender (Lavandula angustifolia) and lemon balm (Melissa officinalis) from Romania.
PubMed: Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities.
PubMed: Chemical composition and antimicrobial and spasmolytic properties of Poliomintha longiflora and Lippia graveolens essential oils.
PubMed: Contact and fumigant toxicity of plant essential oils and efficacy of spray formulations containing the oils against B- and Q-biotypes of Bemisia tabaci.
PubMed: Novel determination of the total phenolic content in crude plant extracts by the use of 1H NMR of the -OH spectral region.
PubMed: Evaluation of oxygen pressurized microwave-assisted digestion of botanical materials using diluted nitric acid.
PubMed: Monoamine reuptake inhibition and mood-enhancing potential of a specified oregano extract.
PubMed: Oxidative stability and microbial growth of turkey breast fillets during refrigerated storage as influenced by feed supplementation with olive leaves, oregano and/or α -tocopheryl acetate.
PubMed: Can glandular hair density be a breeding marker for Origanum vulgare subsp. hirtum with high essential oil content?
PubMed: Repellency to Stomoxys calcitrans (Diptera: Muscidae) of plant essential oils alone or in combination with Calophyllum inophyllum nut oil.
PubMed: Active paraffin-based paper packaging for extending the shelf life of cherry tomatoes.
PubMed: Isolation of quality total RNA from the aromatic plant Origanum onites.
PubMed: Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis.
PubMed: The influence of harvest time on essential oil composition, phenolic constituents and antioxidant properties of Turkish oregano (Origanum onites L.).
PubMed: Systemic induction of monoterpene biosynthesis in Origanumxmajoricum by soil bacteria.
PubMed: Antibacterial effects of allspice, garlic, and oregano essential oils in tomato films determined by overlay and vapor-phase methods.
PubMed: Essential oil composition and antioxidant capacity of Lippia schomburgkiana.
PubMed: Screening of five essential oils for identification of potential inhibitors of IL-1-induced Nf-kappaB activation and NO production in human chondrocytes: characterization of the inhibitory activity of alpha-pinene.
PubMed: Validation of a quantitative assay of arbutin using gas chromatography in Origanum majorana and Arctostaphylos uva-ursi extracts.
PubMed: Comparison of bacteriostatic and bactericidal activity of 13 essential oils against strains with varying sensitivity to antibiotics.
PubMed: Investigation of contribution of individual constituents to antioxidant activity in herbal drugs using postcolumn HPLC method.
PubMed: Enantiomeric composition of (3R)-(-)- and (3S)-(+)-linalool in various essential oils of Indian origin by enantioselective capillary gas chromatography-flame ionization and mass spectrometry detection methods.
PubMed: Enantioselective monoterpene alcohol acetylation in Origanum, Mentha and Salvia species.
PubMed: Rapid and high quality DNA isolation from Origanum onites for RAPD and ISSR analysis.
PubMed: Activity of essential oils and individual components against acetyl- and butyrylcholinesterase.
PubMed: Endosulfan sulfate sorption on natural organic substances.
PubMed: Arsenic, cadmium and lead in medicinal herbs and their fractionation.
PubMed: Ultrasound-assisted dynamic extraction of valuable compounds from aromatic plants and flowers as compared with steam distillation and superheated liquid extraction.
PubMed: Investigation of the antioxidant behavior of air- and freeze-dried aromatic plant materials in relation to their phenolic content and vegetative cycle.
PubMed: Determination of some phenolic acids in Majorana hortensis by capillary electrophoresis with online electrokinetic preconcentration.
PubMed: Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion.
PubMed: Recipes for antimicrobial wine marinades against Bacillus cereus, Escherichia coli O157:H7, Listeria monocytogenes, and Salmonella enterica.
PubMed: Natural compounds of Palestine flora. Comparison analysis by static headspace and steam distillation GC-MS of semivolatile secondary metabolites from leaves of cultivated Palestinian Majorana syriaca.
PubMed: Specific leaf mass, fresh: dry weight ratio, sugar and protein contents in species of Lamiaceae from different light environments.
PubMed: Terpene degradation and extraction from basil and oregano leaves using subcritical water.
PubMed: Arbuscular mycorrhiza alter the concentration of essential oils in oregano (Origanum sp., Lamiaceae).
PubMed: Polar constituents from the aerial parts of Origanum vulgare L. Ssp. hirtum growing wild in Greece.
PubMed: Antimicrobial effects of selected plant essential oils on the growth of a Pseudomonas putida strain isolated from meat.
PubMed: Effect of dried oregano leaves versus neomycin in treating newborn calves with colibacillosis.
PubMed: Supercritical carbon dioxide extraction of compounds with antimicrobial activity from Origanum vulgare L.: determination of optimal extraction parameters.
PubMed: Subcritical water extraction of nutraceuticals with antioxidant activity from oregano. Chemical and functional characterization.
PubMed: Antimicrobial activities of the essential oils of various plants against tomato late blight disease agent Phytophthora infestans.
PubMed: Effect of dietary dried oregano leaves on growth performance, carcase characteristics and serum cholesterol of female early maturing turkeys.
PubMed: In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders.
PubMed: Volatile components and key odorants of fennel (Foeniculum vulgare Mill.) and thyme (Thymus vulgaris L.) oil extracts obtained by simultaneous distillation-extraction and supercritical fluid extraction.
PubMed: Superheated water extraction of essential oils of Origanum micranthum.
PubMed: Effect of solution conductivity on the volatile constituents of Origanum dictamnus L. in nutrient film culture.
PubMed: Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents.
PubMed: Oregano improves reproductive performance of sows.
PubMed: Seasonal, populational and ontogenic variation in the volatile oil content and composition of individuals of Origanum vulgare subsp. Hirtum, assessed by GC headspace analysis and by SPME sampling of individual oil glands.
PubMed: Generalization of a habituated feeding deterrent response to unrelated antifeedants following prolonged exposure in a generalist herbivore, Trichoplusia ni.
PubMed: Antibacterial activities of plant essential oils and their components against Escherichia coli O157:H7 and Salmonella enterica in apple juice.
PubMed: Screening of selected indigenous plants of Lebanon for antimicrobial activity.
PubMed: Superheated water extraction, steam distillation and Soxhlet extraction of essential oils of Origanum onites.
PubMed: Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region.
PubMed: Immunostimulatory effect of dietary oregano etheric oils on lymphocytes from growth-retarded, low-weight growing-finishing pigs and productivity.
PubMed: DPPH radical scavengers from dried leaves of oregano (Origanum vulgare).
PubMed: Screening chemical composition and in vitro antioxidant and antimicrobial activities of the essential oils from Origanum syriacum L. growing in Turkey.
PubMed: Contemporary seasonal and altitudinal variations of leaf structural features in oregano (Origanum vulgare L.).
PubMed: 6-hydroxyflavonoids as alpha-glucosidase inhibitors from marjoram (Origanum majorana) leaves.
PubMed: Protein glycation inhibitory and antioxidative activities of some plant extracts in vitro.
PubMed: The effects of temperature and pressure on the characteristics of the extracts from high-pressure CO(2) extraction of Majorana hortensis Moench.
PubMed: Effect of phosphorus concentration of the nutrient solution on the volatile constituents of leaves and bracts of Origanum dictamnus.
PubMed: Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica.
PubMed: Insecticidal properties of essential plant oils against the mosquito Culex pipiens molestus (Diptera: Culicidae).
PubMed: Antioxidant activity and phenolic compounds in selected herbs.
PubMed: Flavone aglycones in glandular hairs of Origanum x intercedens.
PubMed: Analysis of Origanum vulgare volatiles by direct thermal desorption coupled to gas chromatography-mass spectrometry.
PubMed: Dissimilar phloem loading in leaves with symplasmic or apoplasmic minor-vein configurations.
PubMed: Study of the anatomy and of the essential oil of Origanum cordifolium, an endemic of Cyprus.
PubMed: Volatile Constituents of Origanum dubium Leaves and Stem-Bark.
PubMed: Ultrastructure, organization and cytochemistry of cytoplasmic crystalline inclusions in Origanum dictamnus L. leaf chlorenchyma cells.
PubMed: Effect of volatile substances released from Origanum majorana and Ocimum basilicum on the rhizosphere and phyllosphere fungi of Phaseolus vulgaris.
PubMed: The analysis of essential oils and extracts (oleoresins) from seasonings--a critical review.
PubMed: Effects of some growth hormones on plant vigour and volatile oil of Origanum majorana L.
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