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annatto seed
bixa orellana seed

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Name:bixa orellana seed powder
CAS Number: 1393-63-1
Other(deleted CASRN):1343-85-7
ECHA EC Number:215-735-4
Category:coloring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FEMA Number:2104-VOID annatto seed powder
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):977157-28-0 ; ANNATTO, SEED (BIXA ORELLANA L.)--NLFG
Physical Properties:
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses:
American Botanicals
Annatto Seed
American Natural & Organic Spices
Annatto Seed Whole or Ground, Available as 100% Certified Organic
Blue Pacific Flavors
Annatto Seed Powder
BOC Sciences
For experimental / research use only.
Annatto 95%
Bristol Botanicals
Annatto seed - whole Bixa orellana
Doug Jeffords Company
Annatto, Ground
Indo World Trading
Annato Seeds
Annatto Seed Powder
Penta International
Color-Annatto Powder
Synthite Industries
Annatto: Yellow Red
E-books and Brochures
Whole Herb
Annatto Seed
Safety Information:
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
coloring agents
Recommendation for annatto seed usage levels up to:
 not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: 100.00000100.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Safety References:
European Food Safety Authority (EFSA) reference(s):

Exposure assessment of annatto colouring principles bixin and norbixin (E 160b) when used as food additives
View page or View pdf

Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):1393-63-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
bixa orellana seed powder
 bixa orellana seed powder
Canada Domestic Sub. List:1393-63-1
Pubchem (sid):135208221
Other Information:
FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:3301.29.9090
FDA Listing of Food Additive Status:View
FDA Color Additive Status ListView
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
Search Trop Picture
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PubMed:Safety and efficacy of Bixa orellana (achiote, annatto) leaf extracts.
PubMed:In vitro scavenging capacity of annatto seed extracts against reactive oxygen and nitrogen species.
PubMed:An efficient in vitro propagation methodology for Annatto (Bixa orellana L.).
PubMed:Unraveling new genes associated with seed development and metabolism in Bixa orellana L. by expressed sequence tag (EST) analysis.
PubMed:Inhibition of cyclophosphamide-induced oxidative stress in rat brain by polar and non-polar extracts of Annatto (Bixa orellana) seeds.
PubMed:Hypoglycaemic activity of Bixa orellana extract in the dog.
PubMed:Bioautography and chemical characterization of antimicrobial compound(s) in commercial water-soluble annatto extracts.
PubMed:A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats.
PubMed:Biosynthesis of the food and cosmetic plant pigment bixin (annatto).
PubMed:Drugs used in Africa as dyes: I. Skin absorption and tolerability of Bixa orellana L.
PubMed:Anaphylaxis to annatto dye: a case report.
PubMed:[Analysis of the seed Bixa orellana, L. (annatto) and the waste generated in the extraction of its pigments].
PubMed:[Chemical composition, amino acid content and nutritive value of the protein of the annatto seed (Bixa orellana, L.)].
coloring matter from seeds of bixa orellana l., bixaceae; contains bixin and pigments that give carotene reactions; induces hyperglycemia.
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