plumbago zeylanica flower/root extract
extract of the flowers and roots of plumbago zeylanica l., plumbaginaceae
 
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Name: plumbago zeylanica l. flower/root extract
CAS Number: 92202-07-8 
ECHA EC Number: 296-039-8
Category: antioxidants
 
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
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Safety Information:
 
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Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
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Hazard statement(s)
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Precautionary statement(s)
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Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for plumbago zeylanica flower/root extract usage levels up to:
 not for fragrance use.
 
Recommendation for plumbago zeylanica flower/root extract flavor usage levels up to:
 not for flavor use.
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Safety References:
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 plumbago zeylanica l. flower/root extract
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References:
 plumbago zeylanica l. flower/root extract
Pubchem (cas): 92202-07-8
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Other Information:
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Potential Blenders and core components note
 
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Occurrence (nature, food, other): note
 plumbago zeylanica flower
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Synonyms:
 doctorbush flower/root extract
 extract of the flowers and roots of plumbago zeylanica l., plumbaginaceae
ceylon leadwort flower/root extract
wild leadwort flower/root extract
 plumbago scandens flower/root extract
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Articles:
PubMed: Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach.
PubMed: Comparative toxicity profiles of Plumbago zeylanica L. root petroleum ether, acetone and hydroalcoholic extracts in Wistar rats.
PubMed: Phytogenic silver, gold, and bimetallic nanoparticles as novel antitubercular agents.
PubMed: Plumbagin exerts protective effects in nucleus pulposus cells by attenuating hydrogen peroxide-induced oxidative stress, inflammation and apoptosis through NF-κB and Nrf-2.
PubMed: Plumbagin shows anti-cancer activity in human breast cancer cells by the upregulation of p53 and p21 and suppression of G1 cell cycle regulators.
PubMed: Toxicogenomics of Phenylhydrazine Induced Hematotoxicity and its Attenuation by Plumbagin from Plumbago zeylanica.
PubMed: Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model.
PubMed: Cis-Regulatory Elements Determine Germline Specificity and Expression Level of an Isopentenyltransferase Gene in Sperm Cells of Arabidopsis.
PubMed: Plumbagin shows anticancer activity in human osteosarcoma (MG-63) cells via the inhibition of S-Phase checkpoints and down-regulation of c-myc.
PubMed: Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression.
PubMed: Mechanism of antibacterial action of the alcoholic extracts of Hemidesmus indicus (L.) R. Br. ex Schult, Leucas aspera (Wild.), Plumbago zeylanica L., and Tridax procumbens (L.) R. Br. ex Schult.
PubMed: Ethnomedicinal plants of Kathua district, J&K, India.
PubMed: Population structure and genetic diversity of the perennial medicinal shrub Plumbago.
PubMed: Ethnoveterinary plants for the treatment of camels in Shiwalik regions of Kathua district of Jammu & Kashmir, India.
PubMed: Plumbagin Nanoparticles Induce Dose and pH Dependent Toxicity on Prostate Cancer Cells.
PubMed: Plumbagin induces growth inhibition of human glioma cells by downregulating the expression and activity of FOXM1.
PubMed: High-performance liquid chromatographic quantification of plumbagin from transformed rhizoclones of Plumbago zeylanica L.: inter-clonal variation in biomass growth and plumbagin production.
PubMed: HPTLC Analysis, Antioxidant and Antigout Activity of Indian Plants.
PubMed: Effect of hydro-alcoholic root extract of Plumbago zeylanica l alone and its combination with aqueous leaf extract of Camellia sinensis on haloperidol induced parkinsonism in wistar rats.
PubMed: Antimalarial efficacy of dynamic compound of plumbagin chemical constituent from Plumbago zeylanica Linn (Plumbaginaceae) against the malarial vector Anopheles stephensi Liston (Diptera: Culicidae).
PubMed: Rapid efficient synthesis and characterization of silver, gold, and bimetallic nanoparticles from the medicinal plant Plumbago zeylanica and their application in biofilm control.
PubMed: Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives.
PubMed: Use and management of traditional medicinal plants by Maale and Ari ethnic communities in southern Ethiopia.
PubMed: Activity of Plumbago zeylanica Linn. root and Holoptelea integrifolia Roxb. bark pastes in acute and chronic paw inflammation in Wistar rat.
PubMed: CRM1 is a direct cellular target of the natural anti-cancer agent plumbagin.
PubMed: Plumbagin analogs-synthesis, characterization, and antitubercular activity.
PubMed: Anticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approaches.
PubMed: Ethnobotanical study of Kani tribes in Thoduhills of Kerala, South India.
PubMed: Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice.
PubMed: Ethnomedicinal plants used by the villagers of district Udhampur, J&K, India.
PubMed: Polyketide synthesis in tobacco plants transformed with a Plumbago zeylanica type III hexaketide synthase.
PubMed: Development and Validation of RP-HPLC Method for Simultaneous Estimation of Picroside I, Plumbagin, and Z-guggulsterone in Tablet Formulation.
PubMed: Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions.
PubMed: Plumbagin induces the apoptosis of human tongue carcinoma cells through the mitochondria-mediated pathway.
PubMed: Guanidine alkaloids from Plumbago zeylanica.
PubMed: Plumbagin from Plumbago Zeylanica L induces apoptosis in human non-small cell lung cancer cell lines through NF- κB inactivation.
PubMed: Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model.
PubMed: Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, Stat3 and neuroendocrine markers.
PubMed: Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats.
PubMed: An antileishmanial prenyloxy-naphthoquinone from roots of Plumbago zeylanica.
PubMed: Novel solvent-free gelucire extract of Plumbago zeylanica using non-everted rat intestinal sac method for improved therapeutic efficacy of plumbagin.
PubMed: Determination of potentially toxic heavy metals in traditionally used medicinal plants for HIV/AIDS opportunistic infections in Ngamiland District in Northern Botswana.
PubMed: Old plants newly discovered: Cassia sieberiana D.C. and Cassia abbreviata Oliv. Oliv. root extracts inhibit in vitro HIV-1c replication in peripheral blood mononuclear cells (PBMCs) by different modes of action.
PubMed: Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways.
PubMed: Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway.
PubMed: Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats.
PubMed: Modulation of T cell proliferation and cytokine response by Plumbagin, extracted from Plumbago zeylanica in collagen induced arthritis.
PubMed: Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas.
PubMed: Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-κB signaling pathways.
PubMed: Antigenotoxic effect of the Plumbago zeylanica extract against the genotoxic damage induced by potassium canrenoate in cultured human peripheral blood lymphocytes.
PubMed: The antiviral activity of six South African plants traditionally used against infections in ethnoveterinary medicine.
PubMed: Modulation of plumbagin production in Plumbago zeylanica using a single-chain variable fragment antibody against plumbagin.
PubMed: Synthesis, characterization and preliminary cytotoxicity evaluation of five lanthanide(III)-plumbagin complexes.
PubMed: Larvicidal activities of six plants extracts against two mosquito species, Aedes aegypti and Anopheles stephensi.
PubMed: Antiinflammatory activity of Phyllanthus emblica, Plumbago zeylanica and Cyperus rotundus in acute models of inflammation.
PubMed: Bioefficacy of Plumbago zeylanica (Plumbaginaceae) and Cestrum nocturnum (Solanaceae) plant extracts against Aedes aegypti (Diptera: Culicide) and nontarget fish Poecilia reticulata.
PubMed: Expression, purification, and characterization of anti-plumbagin single-chain variable fragment antibody in Sf9 insect cell.
PubMed: Migration of sperm cells during pollen tube elongation in Arabidopsis thaliana: behavior during transport, maturation and upon dissociation of male germ unit associations.
PubMed: Antimicrobial activities of neo- and 1-epineo-isoshinanolones from Plumbago zeylanica roots.
PubMed: 3β-hydroxylup-20(29)-ene-27,28-dioic acid dimethyl ester, a novel natural product from Plumbago zeylanica inhibits the proliferation and migration of MDA-MB-231 cells.
PubMed: Bioassay-guided isolation of anti-inflammatory and antinociceptive compound from Plumbago zeylanica leaf.
PubMed: [Process comparison of fingerprints of different extracts of Plumbago zeylanica by high performance liquid chromatography].
PubMed: Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 cells.
PubMed: Plumbagin, isolated from Plumbago zeylanica, induces cell death through apoptosis in human pancreatic cancer cells.
PubMed: 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
PubMed: Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry.
PubMed: Larvicidal activity of extracts from three Plumbago spp against Anopheles gambiae.
PubMed: Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo.
PubMed: [Analysis of macroelements and microelements in Chinese traditional medicine Plumbago zeylanica Linn by ICP-AES].
PubMed: Mutagenic screening of some commonly used medicinal plants in Nigeria.
PubMed: Determination of psoralen and plumbagin from its polyherbal oil formulations by an HPTLC densitometric method.
PubMed: Antifertility activity of leaves of Plumbago zeylanica Linn. in female albino rats.
PubMed: Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells.
PubMed: Gene expression in the dimorphic sperm cells of Plumbago zeylanica: transcript profiling, diversity, and relationship to cell type.
PubMed: Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes.
PubMed: Potential genotoxicity of plant extracts used in Ethiopian traditional medicine.
PubMed: Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells.
PubMed: Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer.
PubMed: A Reverse Phase HPLC-UV and HPTLC Methods for Determination of Plumbagin in Plumbago indica and Plumbago zeylanica.
PubMed: Antimutagenic activity of methanolic extracts of four ayurvedic medicinal plants.
PubMed: Seselin from Plumbago zeylanica inhibits phytohemagglutinin (PHA)-stimulated cell proliferation in human peripheral blood mononuclear cells.
PubMed: Toxicity studies on dermal application of plant extract of Plumbago zeylanica used in Ethiopian traditional medicine.
PubMed: Fungal contamination of raw materials of some herbal drugs and recommendation of Cinnamomum camphora oil as herbal fungitoxicant.
PubMed: Plumbagin-induced apoptosis in human prostate cancer cells is associated with modulation of cellular redox status and generation of reactive oxygen species.
PubMed: Contraceptive efficacy of Plumbago zeylanica root extract (50% etoh) in male albino rats with special emphasis on testicular cell population dynamics.
PubMed: Development of an enzyme-linked immunosorbent assay (ELISA) using highly-specific monoclonal antibodies against plumbagin.
PubMed: [Chemical constituents from aerial parts of Plumbago zeylanica Linn].
PubMed: Herbs containing L- Dopa: An update.
PubMed: Antibacterial properties of traditionally used Indian medicinal plants.
PubMed: [Determination of plumbagin in different parts of Plumbago zeylanica by RP-HPLC].
PubMed: Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-kappaB.
PubMed: Medicinal plants of the Shinasha, Agew-awi and Amhara peoples in northwest Ethiopia.
PubMed: Evaluation of anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and synergy of some bioactive plant extracts.
PubMed: In vitro efficacy of bioactive extracts of 15 medicinal plants against ESbetaL-producing multidrug-resistant enteric bacteria.
PubMed: Measurement and pharmacokinetic study of plumbagin in a conscious freely moving rat using liquid chromatography/tandem mass spectrometry.
PubMed: Protective effect of Plumbago zeylanica against cyclophosphamide-induced genotoxicity and oxidative stress in Swiss albino mice.
PubMed: [Effects of plumbagin on the human acute promyelocytic leukemia cells in vitro].
PubMed: Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
PubMed: Plumbago zeylanica action on blood coagulation profile with and without blood volume reduction.
PubMed: A highly efficient in vitro plant regeneration system and Agrobacterium-mediated transformation in Plumbago zeylanica.
PubMed: Antioxidant activity of a salt-spice-herbal mixture against free radical induction.
PubMed: In vivo micronucleus assay and GST activity in assessing genotoxicity of plumbagin in Swiss albino mice.
PubMed: High-performance liquid chromatography for quantification of plumbagin, an anti-Helicobacter pylori compound of Plumbago zeylanica L.
PubMed: Antiviral activities of some Ethiopian medicinal plants used for the treatment of dermatological disorders.
PubMed: Determination and identification of plumbagin from the roots of Plumbago zeylanica L. by liquid chromatography with tandem mass spectrometry.
PubMed: Anti-Helicobacter pylori activity of Plumbago zeylanica L.
PubMed: Screening of anti-Helicobacter pylori herbs deriving from Taiwanese folk medicinal plants.
PubMed: Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide.
PubMed: Antioxidant properties of Plumbago zeylanica, an Indian medicinal plant and its active ingredient, plumbagin.
PubMed: Cytotoxic constituents from Plumbago zeylanica.
PubMed: Inhibition of immediate allergic reactions by ethanol extract from Plumbago zeylanica stems.
PubMed: [Effects of the water-soluble extracts from the single herb of ganduqing against hepatitis B virus in vitro].
PubMed: Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.
PubMed: Central nervous system stimulatory action from the root extract of Plumbago zeylanica in rats.
PubMed: In vitro screening of Indian medicinal plants for antiplasmodial activity.
PubMed: An investigation into the biochemical basis of the observed hyperglycaemia in rats treated with ethanol root extract of plumbago zeylanica.
PubMed: Isolation and collection of two populations of viable sperm cells from the pollen of Plumbago zeylanica.
PubMed: Screening of some Indian medicinal plants for their antimicrobial properties.
PubMed: Modulatory effect of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) on macrophage functions in BALB/c mice. I. Potentiation of macrophage bactericidal activity.
PubMed: Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma.
PubMed: Cytoskeletal organisation and modification during pollen tube arrival, gamete delivery and fertilisation in Plumbago zeylanica.
PubMed: A new disease of plumbago zeylanica L.
PubMed: Effect of Plumbago zeylanica root powder induced preimplantationary loss and abortion on uterine luminal proteins in albino rats.
PubMed: Hypolipidaemic and antiatherosclerotic effects of plumbagin in rabbits.
PubMed: Effects of plumbagin on antibiotic resistance in bacteria.
PubMed: Isolation of Fixed and Viable Eggs, Central Cells, and Embryo Sacs from Ovules of Plumbago zeylanica.
PubMed: Two-Dimensional Electrophoretic Studies of the Proteins and Polypeptides in Mature Pollen Grains and the Male Germ Unit of Plumbago zeylanica.
PubMed: Quantitative cytology of the egg and central cell of Plumbago zeylanica and its impact on cytoplasmic inheritance patterns.
PubMed: Isolation of Sperm Cells from the Pollen of Plumbago zeylanica.
PubMed: Preferential fertilization in Plumbago: Ultrastructural evidence for gamete-level recognition in an angiosperm.
PubMed: Ultrastructure of the sperm of Plumbago zeylanica : II. Quantitative cytology and three-dimensional organization.
PubMed: Antifertility activity of Plumbago zeylanica Linn. root.
PubMed: Folklore information from Assam for family planning and birth control.
PubMed: Research on plants for fertility regulation in India.
PubMed: Participation of Male Cytoplasm During Gamete Fusion in an Angiosperm, Plumbago zeylanica.
PubMed: Ultrastructural organization of the egg of Plumbago zeylanica.
PubMed: The constituents in the roots of Plumbago auriculata Lam. and Plumbago zeylanica L. responsible for antibacterial activity.
PubMed: Plumbago zeylanica L. (Chitrak). A gastrointestinal flora normaliser.
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