angelica gigas extract
extract of the plant, angelica gigas, apiaceae
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Category: cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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 None found
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic ingredient for skin conditioning
Recommendation for angelica gigas extract usage levels up to:
 not for fragrance use.
Recommendation for angelica gigas extract flavor usage levels up to:
 not for flavor use.
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Safety References:
None found
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None found
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 angelica gigas
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 chao xian dang gui extract
 extract of the plant, angelica gigas, apiaceae
 oni-nodake extract
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PubMed: Effect of nodakenin on atopic dermatitis-like skin lesions.
PubMed: Decursin attenuates kainic acid-induced seizures in mice.
PubMed: Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice.
PubMed: An ethanolic extract of Angelica gigas improves atherosclerosis by inhibiting vascular smooth muscle cell proliferation.
PubMed: Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling.
PubMed: Development of a pharmacokinetic/pharmacodynamic/disease progression model in NC/Nga mice for development of novel anti-atopic dermatitis drugs.
PubMed: Anti-inflammatory and anti-proliferative effect of herbal medicines (APR) in RAW264.7 cells.
PubMed: Decursin prevents TPA-induced invasion through suppression of PKCα/p38/NF-κB-dependent MMP-9 expression in MCF-7 human breast carcinoma cells.
PubMed: Two novel Talaromyces species isolated from medicinal crops in Korea.
PubMed: Preventative effect of an herbal preparation (HemoHIM) on development of airway inflammation in mice via modulation of Th1/2 cells differentiation.
PubMed: A New Herbal Formula, KSG-002, Suppresses Breast Cancer Growth and Metastasis by Targeting NF- κ B-Dependent TNF α Production in Macrophages.
PubMed: Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells.
PubMed: Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK.
PubMed: Decursin exerts anti-cancer activity in MDA-MB-231 breast cancer cells via inhibition of the Pin1 activity and enhancement of the Pin1/p53 association.
PubMed: Single oral dose pharmacokinetics of decursin, decursinol angelate, and decursinol in rats.
PubMed: A (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]-chromen-3-yl-ester, attenuates the development of atopic dermatitis-like lesions in NC/Nga mice.
PubMed: New discrimination method combining hit quality index based spectral matching and voting.
PubMed: Decursin inhibits UVB-induced MMP expression in human dermal fibroblasts via regulation of nuclear factor-κB.
PubMed: Ultrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: particle size effect.
PubMed: Biopharmaceutical characterization of decursin and their derivatives for drug discovery.
PubMed: The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or Aβ(1-42)-induced cognitive dysfunction in mice.
PubMed: Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia.
PubMed: Physicochemical characterization and toxicity of decursin and their derivatives from Angelica gigas.
PubMed: Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds.
PubMed: First-pass metabolism of decursin, a bioactive compound of Angelica gigas, in rats.
PubMed: Food- and gender-dependent pharmacokinetics of paeoniflorin after oral administration with Samul-tang in rats.
PubMed: Neuroprotective effects of INM-176 against lipopolysaccharide-induced neuronal injury.
PubMed: Decursin inhibits vasculogenesis in early tumor progression by suppression of endothelial progenitor cell differentiation and function.
PubMed: Chemometric classification of morphologically similar Umbelliferae medicinal herbs by DART-TOF-MS fingerprint.
PubMed: Quantitative determination of decursin, decursinol angelate, and decursinol in mouse plasma and tumor tissue using liquid-liquid extraction and HPLC.
PubMed: Decursin, an active compound isolated from Angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet.
PubMed: The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study.
PubMed: A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo.
PubMed: Anti-allergic effects and mechanisms of action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene-induced inflammation models.
PubMed: Metabolite profiling of Angelica gigas from different geographical origins using 1H NMR and UPLC-MS analyses.
PubMed: Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats.
PubMed: Overexpression of cinnamate 4-hydroxylase gene enhances biosynthesis of decursinol angelate in Angelica gigas hairy roots.
PubMed: Immunotoxicity activity from various essential oils of Angelica genus from South Korea against Aedes aegypti L.
PubMed: Antiplasmodial and cytotoxic activity of coumarin derivatives from dried roots of Angelica gigas Nakai in vitro.
PubMed: Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymes.
PubMed: Decursin and decursinol from Angelica gigas inhibit the lung metastasis of murine colon carcinoma.
PubMed: Enhancement of pheochromocytoma nerve cell growth by consecutive fractionization of Angelica gigas Nakai extracts.
PubMed: Cloning and characterization of phenylalanine ammonia-lyase and cinnamate 4-hydroxylase and pyranocoumarin biosynthesis in Angelica gigas.
PubMed: Decursin prevents cisplatin-induced apoptosis via the enhancement of antioxidant enzymes in human renal epithelial cells.
PubMed: A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease.
PubMed: A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease.
PubMed: Synergistic vasorelaxant and antihypertensive effects of Ligusticum wallichii and Angelica gigas.
PubMed: Decursinol angelate blocks transmigration and inflammatory activation of cancer cells through inhibition of PI3K, ERK and NF-kappaB activation.
PubMed: Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation.
PubMed: Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway.
PubMed: Biotransformation of plant secondary metabolite decursin by Mycobacterium sp. PYR1001.
PubMed: Absorption, distribution, metabolism, and excretion of decursin and decursinol angelate from Angelica gigas Nakai.
PubMed: Antiproliferative activity of Korean wild vegetables on different human tumor cell lines.
PubMed: Evaluation of the phototoxic potential of plants used in oriental medicine.
PubMed: Anti-inflammatory effects of an ethanol extract of Angelica gigas in a Carrageenan-air pouch inflammation model.
PubMed: The analgesic effect of decursinol.
PubMed: ESP-102, a combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, protects against glutamate-induced toxicity in primary cultures of rat cortical cells.
PubMed: Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase.
PubMed: Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway.
PubMed: In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin.
PubMed: Antidiabetic activity of angelan isolated from Angelica gigas Nakai.
PubMed: In vitro inhibitory potential of decursin and decursinol angelate on the catalytic activity of cytochrome P-450 1A1/2, 2D15, and 3A12 isoforms in canine hepatic microsomes.
PubMed: Identification of proteins binding to decursinol by chemical proteomics.
PubMed: Inhibitory effects of Angelicae Gigantis Radix on osteoclast formation.
PubMed: Antioxidant activity and cytotoxicity of methanol extracts from aerial parts of Korean salad plants.
PubMed: Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships.
PubMed: Simultaneous determination of eight coumarins in Angelica gigas and in various other Angelica species by high performance liquid chromatography and comparative micro-morphology study of Angelica species.
PubMed: The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry.
PubMed: Decursin and decursinol angelate selectively inhibit NADH-fumarate reductase of Ascaris suum.
PubMed: Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells.
PubMed: Decursin suppresses human androgen-independent PC3 prostate cancer cell proliferation by promoting the degradation of beta-catenin.
PubMed: Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents.
PubMed: Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity.
PubMed: Mechanism-based inactivation of cytochrome P450 2A6 by decursinol angelate isolated from Angelica Gigas.
PubMed: Development of gas chromatographic/mass spectrometry-pattern recognition method for the quality control of Korean Angelica.
PubMed: Optimized conditions for the extraction of secondary volatile metabolites in Angelica roots by accelerated solvent extraction.
PubMed: Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice.
PubMed: Transport of decursin and decursinol angelate across Caco-2 and MDR-MDCK cell monolayers: in vitro models for intestinal and blood-brain barrier permeability.
PubMed: Volatile organic compounds of Angelica gigas Nakai, Korean medicinal herb.
PubMed: A novel class of pyranocoumarin anti-androgen receptor signaling compounds.
PubMed: Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4.
PubMed: Identification of volatile components in Angelica species using supercritical-CO2 fluid extraction and solid phase microextraction coupled to gas chromatography-mass spectrometry.
PubMed: Determination of volatile flavor components in danggui cultivars by solvent free injection and hydrodistillation followed by gas chromatographic-mass spectrometric analysis.
PubMed: Pectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functions.
PubMed: Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer.
PubMed: The essential oil from Angelica gigas NAKAI suppresses nicotine sensitization.
PubMed: New anti-inflammatory formulation containing Synurus deltoides extract.
PubMed: Decursin and PDBu: two PKC activators distinctively acting in the megakaryocytic differentiation of K562 human erythroleukemia cells.
PubMed: Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia cells.
PubMed: A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells.
PubMed: ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice.
PubMed: Four new neuroprotective dihydropyranocoumarins from Angelica gigas.
PubMed: Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometry.
PubMed: Protection against beta-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice.
PubMed: Anti-tumor activities of decursinol angelate and decursin from Angelica gigas.
PubMed: Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models.
PubMed: Antibacterial coumarins from Angelica gigas roots.
PubMed: Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice.
PubMed: Experimental evidences and signal transduction pathways involved in the activation of NF-kappa B/Rel by angelan in murine macrophages.
PubMed: Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.
PubMed: Activation of mitogen-activated protein kinase pathways by angelan in murine macrophages.
PubMed: Differential activation of murine macrophages by angelan and LPS.
PubMed: Polyacetylenes from angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages.
PubMed: Activation of NF-kappaB/Rel in angelan-stimulated macrophages.
PubMed: Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai.
PubMed: Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
PubMed: Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas.
PubMed: Coumarins from the root of Angelica gigas Nakai.
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