coptis japonica extract
extract of the whole plant of coptis japonica, ranunculaceae
 
Notes:
None found
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Name: coptis japonica extract
CAS Number: 223748-66-1 
Category: cosmetic agents
 
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Physical Properties:
Food Chemicals Codex Listed: No
Soluble in:
 alcohol
Insoluble in:
 water
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antidandruff agents
antimicrobial agents
hair conditioning
skin conditioning
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for coptis japonica extract usage levels up to:
 not for fragrance use.
 
Recommendation for coptis japonica extract flavor usage levels up to:
 not for flavor use.
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Safety References:
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 coptis japonica extract
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References:
 coptis japonica extract
Pubchem (cas): 223748-66-1
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 coptis japonica
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Synonyms:
 extract of the whole plant of coptis japonica, ranunculaceae
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Articles:
PubMed: Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells.
PubMed: Anti-adipogenic activity of berberine is not mediated by the WNT/β-catenin pathway.
PubMed: Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants.
PubMed: Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells.
PubMed: Characterization of Coptis japonica CjABCB2, an ATP-binding cassette protein involved in alkaloid transport.
PubMed: Modulations of cytochrome P450 expression in diabetic mice by berberine.
PubMed: Basic helix-loop-helix transcription factors and regulation of alkaloid biosynthesis.
PubMed: Isoquinoline alkaloid biosynthesis is regulated by a unique bHLH-type transcription factor in Coptis japonica.
PubMed: Norcoclaurine synthase is a member of the pathogenesis-related 10/Bet v1 protein family.
PubMed: Molecular characterization of O-methyltransferases involved in isoquinoline alkaloid biosynthesis in Coptis japonica.
PubMed: Identification of regulatory protein genes involved in alkaloid biosynthesis using a transient RNAi system.
PubMed: Metabolic diversification of benzylisoquinoline alkaloid biosynthesis through the introduction of a branch pathway in Eschscholzia californica.
PubMed: Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry.
PubMed: Improved accumulation of ajmalicine and tetrahydroalstonine in Catharanthus cells expressing an ABC transporter.
PubMed: Isolation of herbicide-resistant 4-hydroxyphenylpyruvate dioxygenase from cultured Coptis japonica cells.
PubMed: CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica.
PubMed: Galactinol synthase gene of Coptis japonica is involved in berberine tolerance.
PubMed: Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells.
PubMed: Molecular cloning and characterization of Crmdr1, a novel MDR-type ABC transporter gene from Catharanthus roseus.
PubMed: Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy.
PubMed: Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica.
PubMed: Functional analysis of norcoclaurine synthase in Coptis japonica.
PubMed: Overexpression of Coptis japonica norcoclaurine 6-O-methyltransferase overcomes the rate-limiting step in Benzylisoquinoline alkaloid biosynthesis in cultured Eschscholzia californica.
PubMed: Bowman-birk proteinase inhibitor confers heavy metal and multiple drug tolerance in yeast.
PubMed: Identification of a WRKY protein as a transcriptional regulator of benzylisoquinoline alkaloid biosynthesis in Coptis japonica.
PubMed: Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino.
PubMed: Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice.
PubMed: Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells.
PubMed: Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica.
PubMed: Coptis japonica root extract induces apoptosis through caspase3 activation in SNU-668 human gastric cancer cells.
PubMed: Transient RNA silencing of scoulerine 9-O-methyltransferase expression by double stranded RNA in Coptis japonica protoplasts.
PubMed: In vivo bioconversion of tetrahydroisoquinoline by recombinant coclaurine N-methyltransferase.
PubMed: Immunoquantitative analysis for berberine and its related compounds using monoclonal antibodies in herbal medicines.
PubMed: (R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy.
PubMed: Antimalarial activity of herbal extracts used in traditional medicine in Korea.
PubMed: Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy.
PubMed: Effects of Coptis japonica on morphine-induced conditioned place preference in mice.
PubMed: Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells.
PubMed: Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells.
PubMed: Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins.
PubMed: Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica.
PubMed: Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids.
PubMed: Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells.
PubMed: Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.
PubMed: Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica.
PubMed: Herbological studies of Coptidis rhizoma (Part 2): on the old Japanese name of Coptis japonica makino.
PubMed: Lignans from the rhizomes of Coptis japonica differentially act as anti-inflammatory principles.
PubMed: A novel Coptis japonica multidrug-resistant protein preferentially expressed in the alkaloid-accumulating rhizome.
PubMed: Purification and characterization of coclaurine N-methyltransferase from cultured Coptis japonica cells.
PubMed: Metabolic engineering of plant alkaloid biosynthesis.
PubMed: In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica.
PubMed: Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp.
PubMed: Antifeeding activity of isoquinoline alkaloids identified in Coptis japonica roots against Hyphantria cunea (Lepidoptera: Arctiidae) and Agelastica coerulea (Coleoptera: Galerucinae).
PubMed: Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica.
PubMed: Antiphotooxidative activity of protoberberines derived from Coptis japonica makino in the chlorophyll-sensitized photooxidation of oil.
PubMed: Growth-inhibiting effects of Coptis japonica root-derived isoquinoline alkaloids on human intestinal bacteria.
PubMed: Antitrypanosomal effects of traditional Chinese herbal medicines on bloodstream forms of Trypanosoma brucei rhodesiense in vitro.
PubMed: Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated RAW264.7 cells.
PubMed: Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT.
PubMed: Inhibitory effects of protoberberine alkaloids from the roots of Coptis japonica on catecholamine biosynthesis in PC12 cells.
PubMed: [Study on baths with crude drug. II.: the effects of coptidis rhizoma extracts as skin permeation enhancer].
PubMed: Molecular cloning and characterization of S-adenosyl-L-methionine:scoulerine-9-O-methyltransferase from cultured cells of Coptis japonica.
PubMed: Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells.
PubMed: [Comparative studies on concentration of berberine in plasma after oral administration of coptidis rhizoma extract, its cultured cells extract, and combined use of these extracts and glycyrrhizae radix extract in rats].
PubMed: The Norcoclaurine Pathway is Operative in Berberine Biosynthesis in Coptis japonica.
PubMed: Specific differences in tolerance to exogenous berberine among plant cell cultures.
PubMed: [Evaluation on equivalence of pharmacological properties between natural crude drugs and their cultured cells based on their components. Accelerative effect of lithospermi radix and inhibitory effect of coptidis rhizoma on proliferation of granulation tissue].
PubMed: Flow Cytometric Analysis of Cellular Berberine Contents in High- and Low-Producing Cell Lines of Coptis japonica Obtained by Repeated Selection.
PubMed: Isolation, sequence, and bacterial expression of a cDNA for (S)-tetrahydroberberine oxidase from cultured berberine-producing Coptis japonica cells.
PubMed: Effects of certain herbal medicines on the biotransformation of arachidonic acid: a new pharmacological testing method using serum.
PubMed: Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures.
PubMed: A new estimation method for plant cell viability by determining electron transport activity.
PubMed: Cytological changes associated with alkaloid production in cultured cells of Coptis japonica and Thalictrum minus.
PubMed: Instability of chromosomes and alkaloid content in cell lines derived from single protoplasts of cultured Coptis japonica cells.
PubMed: [Studies on anti-inflammatory agents. II. Anti-inflammatory constituents from Rhizome of Coptis japonica Makino (author's transl)].
PubMed: Effect of plant alkaloid against the action of herpes simplex type 1 in experimental corneal herpes in rabbits: the effect of an aqueous extract of Coptis japonica Makino against herpes simplex.
PubMed: Studies on the components of the leaves of Coptis japonica Makino. I. The structures of coptiside I and II.
PubMed: [Cultivation experiments of Coptis japonica Makino. I. Effect of light intensity on the growth and yield].
PubMed: [STUDIES ON THE QUANTITATIVE ANALYSIS OF CONSTITUENTS IN CRUDE DRUGS BY THIN-LAYER CHROMATOGRAPHY. I. STUDIES ON THE QUANTITATIVE ANALYSIS OF BERBERINE IN COPTIS JAPONICA MAKINO BY THIN-LAYER CHROMATOGRAPHY].
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