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cnidium monnieri fruit extract
extract of the fruit of cnidium monnieri, apiaceae

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Category:humectants, skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: humectants
skin conditioning
AuNutra® Industries
Cnidium Fruit P.E
Changsha Organic Herb
Common Cnidium Fruit Extract
Jiangyin Healthway
Cnidium fruits P.E.
New functional food ingredients
Shaanxi Y-Herb Biotechnology
Fructus Cnidii P.E. Common Cnidium Monnieri Fruit Extract 10%-98% Osthole Powder
Xi'an Greena Biotech
Cnidium Monnieri Extract
Odor: characteristic
Use: Cnidium monnieri is a plant which grows in China whose fruit, seed, and other plant parts are used as medicine.It is known in China as She Chuang Zi.Cnidium has been used in Traditional Chinese Medicine (TCM) for thousands of years,often for a variety of skin ailments and as a reproductive aid and aphrodisiac that increases sexual desire in both men and women.Cnidium seed contains several compounds including osthole,bornyl isovalarate,osthol, bergapten,isopimpinellin, columbianetin and other active ingredients.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
humectants, skin conditioning
Recommendation for cnidium monnieri fruit extract usage levels up to:
 not for fragrance use.
Recommendation for cnidium monnieri fruit extract flavor usage levels up to:
 not for flavor use.
Safety References:
None found
None found
Other Information:
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 cnidium monnieri fruit
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 extract of the fruit of cnidium monnieri, apiaceae


PubMed:8-Alkylcoumarins from the fruits of Cnidium monnieri protect against hydrogen peroxide induced oxidative stress damage.
PubMed:Osthole regulates TGF-β1 and MMP-2/9 expressions via activation of PPARα/γ in cultured mouse cardiac fibroblasts stimulated with angiotensin II.
PubMed:Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis.
PubMed:Osthole induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
PubMed:Bioavailability enhancement of osthole after oral administration of Bushen Yizhi prescription extract to rats followed by Cnidium monnieri (L.) Cusson fruits extract in comparison to pure osthole at different doses.
PubMed:N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo.
PubMed:Suppression of voltage-gated Na(+) channels and neuronal excitability by imperatorin.
PubMed:Osthole attenuates spinal cord ischemia-reperfusion injury through mitochondrial biogenesis-independent inhibition of mitochondrial dysfunction in rats.
PubMed:A new phenolic glycoside from Cnidium monnieri fruits.
PubMed:Protective effects of osthole against myocardial ischemia/reperfusion injury in rats.
PubMed:Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia.
PubMed:NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats.
PubMed:Osthole Improves Spatial Memory Deficits in Rats via Hippocampal α 1-Adrenergic and D 1 /D 2 Receptors.
PubMed:Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology.
PubMed:A rapid and sensitive LC-MS/MS method for the determination of osthole in rat plasma: application to pharmacokinetic study.
PubMed:Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae.
PubMed:Herbal medicines for the prevention of alcoholic liver disease: a review.
PubMed:Anti-adipogenic chromone glycosides from Cnidium monnieri fruits in 3T3-L1 cells.
PubMed:Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro.
PubMed:Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism.
PubMed:Osthole attenuates focal inflammatory reaction following permanent middle cerebral artery occlusion in rats.
PubMed:Isolation and identification of metabolites of osthole in rats.
PubMed:Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti.
PubMed:Mechanism of osthole inhibition of vascular Ca(v)1.2 current.
PubMed:Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats.
PubMed:[Preparation of water in oil type cream with high content of water containing Kochia scoparia fruit and Cnidium monnieri fruit].
PubMed:Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings.
PubMed:Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity.
PubMed:Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated mice.
PubMed:Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression.
PubMed:Chromones and coumarins from the dried fructus of Cnidium monnieri.
PubMed:Neuroprotective effect of osthole against oxygen and glucose deprivation in rat cortical neurons: involvement of mitogen-activated protein kinase pathway.
PubMed:Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells.
PubMed:Discovery of novel osthole derivatives as potential anti-breast cancer treatment.
PubMed:Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress.
PubMed:Osthole regulates inflammatory mediator expression through modulating NF-κB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species.
PubMed:Effects of osthole on migration and invasion in breast cancer cells.
PubMed:Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production.
PubMed:Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway.
PubMed:Effects of osthole on apoptosis and TGF-beta1 of hypertrophic scar fibroblasts.
PubMed:Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine.
PubMed:Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
PubMed:Computational screening and design of traditional Chinese medicine (TCM) to block phosphodiesterase-5.
PubMed:Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice.
PubMed:Herbal plants as a promising source of natural antifoulants: evidence from barnacle settlement inhibition.
PubMed:Identification and quantification of the volatile constituents in Cnidium monnieri using supercritical fluid extraction followed by GC-MS.
PubMed:Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells.
PubMed:Analysis of Cnidium monnieri fruits in different regions of China.
PubMed:Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals.
PubMed:Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats.
PubMed:Micelle-mediated extraction and cloud-point preconcentration of osthole and imperatorin from Cnidium monnieri with analysis by high performance liquid chromatography.
PubMed:Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats.
PubMed:Inhibitory effect of osthole on alcohol-induced fatty liver in mice.
PubMed:[Chromatographic fingerprint of Cnidium monnieri].
PubMed:Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.
PubMed:Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats.
PubMed:Coumarins from Cnidium monnieri and their antiosteoporotic activity.
PubMed:Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study.
PubMed:Fingerprint analysis of the fruits of Cnidium monnieri extract by high-performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry.
PubMed:[Inhibitory effects of natural plant extracts on Verticillium albo-atrum].
PubMed:Comparison of micellar electrokinetic capillary chromatography and high performance liquid chromatography on fingerprint of Cnidium monnieri.
PubMed:[Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri].
PubMed:Simultaneous separation and purification of five bioactive coumarins from the Chinese medicinal plant Cnidium monnieri by high-speed counter-current chromatography.
PubMed:[Synthetical evaluation of promoting effect of some kinds of transdermal enhancers with grey relational cluster method].
PubMed:Preparative isolation and purification of bergapten and imperatorin from the medicinal plant Cnidium monnieri using high-speed counter-current chromatography by stepwise increasing the flow-rate of the mobile phase.
PubMed:Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography.
PubMed:[Analysis on intraspecific variation of Cnidium monnieri by RAPD].
PubMed:Coumarins from Cnidium monnieri (L.) and their proliferation stimulating activity on osteoblast-like UMR106 cells.
PubMed:Preparative isolation of osthol and xanthotoxol from Common Cnidium Fruit (Chinese traditional herb) using stepwise elution by high-speed counter-current chromatography.
PubMed:Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines.
PubMed:The ameliorating effects of cognition-enhancing Chinese herbs on scopolamine- and MK-801-induced amnesia in rats.
PubMed:[Advances in the study of chemical constituents and pharmacological actions of Cnidium monnieri (L.) Cusson].
PubMed:Antipruritic effects of Sophora flavescens on acute and chronic itch-related responses in mice.
PubMed:[Determination of chemical constituents of the essential oil from Cnidium monnieri by GC-MS].
PubMed:[Microscopic and TLC identification on the fruits of ten species plants for Umbelliferae].
PubMed:Total coumarins from fruits of Cnidium monnieri inhibit formation and differentiation of multinucleated osteoclasts of rats.
PubMed:Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells.
PubMed:Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol.
PubMed:Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON).
PubMed:Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells.
PubMed:Glucides of Cnidium monnieri fruit.
PubMed:Inhibition of itch-scratch response by fruits of Cnidium monnieri in mice.
PubMed:Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum.
PubMed:Inhibitory effects of methanol extracts of herbal medicines on substance P-induced itch-scratch response.
PubMed:Coumarins from the fruits of Cnidium monnieri.
PubMed:Effects of total coumarins of Cnidium monnieri on bone density and biomechanics of glucocorticoids-induced osteoporosis in rats.
PubMed:[Effects of fructus cnidii coumarins compared with nilestriol on osteoporosis in ovariectomized rats].
PubMed:[Effects of coumarins from cnidium monnieri on the function of pituitary-adrenocortical axis in kidney yang deficiency rats].
PubMed:[Interspecific difference and intraspecific variation of coumarins in Cnidium species].
PubMed:[Effects of osthol and total-coumarins from Cnidium monnieri on immunological function in kidney yang deficiency mice].
PubMed:[Effect of total coumarins from dried fruits of Cnidium monnieri on glucocorticoid-induced osteoporosis in rats].
PubMed:[Effects of total coumarins, essential oil and water extracts of Cnidium monnieri on plasma prostaglandin and cyclic nucleotide in the rats of kidney-yang insufficiency].
PubMed:[A pharmacognostical study on the fruits of Cnidium monnieri (L.) Cuss].
PubMed:[Antimutagenicity screening of water extracts from 102 kinds of Chinese medicinal herbs].
PubMed:[Mechanism of the antiasthmatic effect of total coumarins in the fruit of Cnidium monnieri (L.)Cuss].
PubMed:[Determination of osthol and imperatorin in Cnidium monnieri (L.) cuss by fluorometry TLC scanning].
PubMed:[Antimutagenicity assays of water extracted from the fruits of Cnidium monnieri (L.) cuss].
PubMed:[Local anesthetic effect of an aqueous extract from the seeds of Cnidium monnieri (L.) Cusson].
PubMed:[The anti-allergic activity of osthol extracted from the fruits of Cnidium monnieri (L.) Cusson].
PubMed:Determination of coumarins in Cnidium monnieri fructus by high-performance liquid chromatography.
PubMed:[Pharmacological study of total coumarins in the fruit of Cnidium monnieri].
None found
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