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magnolia officinalis bark extract
extract of the bark of magnolia officinalis, magnoliaceae

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Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
skin conditioning
AuNutra® Industries
Officinal Magnolia P.E.
O'Laughlin Industries
Honokiol 10% min., Magnolol 10% min., Total H/M 30% min.
O'Laughlin Industries
Honokiol 30% min., Magnolol 30% min., Total H/M 85% min.
O'Laughlin Industries
Honokiol 30% min., Magnolol 30% min., Total H/M 90% min.
O'Laughlin Industries
Honokiol 30% min., Magnolol 30% min., Total H/M 95% min.
O'Laughlin Industries
O'Laughlin Industries
Honokiol 15.9% min., Magnolol 22.6% min.
Qingdao Dacon Trading
Magnolia Bark Extract
Shaanxi Haokang Bio-technology
Magnolia Bark Extract (10:1, 20:1, 30:1)
Xi'an Greena Biotech
Magnolia Bark Extract
Odor: characteristic
Use: Magnolia bark (Magnolia officinalis) is a traditional Chinese medicine used since 100 A.D. The plant belongs to the Magnoliaceae family of herbs and has more than 200 related species under its fold.This herb is aromatic, pungent, warming and stimulating. Magnolia bark may have antiseptic, antifungal, antibacterial, anti-inflammatory and antispasmodic properties and may be used to treat various inflammatory conditions, colds and flu.In addition, magnolia bark is said to promote sleep, support weight loss, stimulate the digestive system, protect against cancer, and reduce stress.Magnolol and honokiol are the two primary active phenolic constituents of magnolia bark Extract.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for magnolia officinalis bark extract usage levels up to:
 not for fragrance use.
Recommendation for magnolia officinalis bark extract flavor usage levels up to:
 not for flavor use.
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
None found
Other Information:
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 magnolia officinalis bark
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 extract of the bark of magnolia officinalis, magnoliaceae
houpu magnolia bark extract


PubMed:Potential use of Magnolia officinalis bark polyphenols in the treatment of cannabis dependence.
PubMed:Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia.
PubMed:Magnolol causes alterations in the cell cycle in androgen insensitive human prostate cancer cells in vitro by affecting expression of key cell cycle regulatory proteins.
PubMed:Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells.
PubMed:Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol.
PubMed:Magnolol Inhibits Tumor Necrosis Factor-α-Induced ICAM-1 Expression via Suppressing NF-κB And MAPK Signaling Pathways in Human Lung Epithelial Cells.
PubMed:Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway.
PubMed:Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects.
PubMed:Chemopreventive effects of combination of honokiol and magnolol with α-santalol on skin cancer developments.
PubMed:Phenolic glycosides and other constituents from the bark of Magnolia officinalis.
PubMed:Studies on the alkaloids of the bark of Magnolia officinalis: isolation and on-line analysis by HPLC-ESI-MS(n).
PubMed:Identification of Magnolia officinalis L. bark extract as the most potent anti-inflammatory of four plant extracts.
PubMed:Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression.
PubMed:P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo.
PubMed:Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells.
PubMed:Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55.
PubMed:[The relationship between the quality and the leaf shape of Magnolia officinalis produced in Hubei enshi].
PubMed:Apoptosis-inducing and antitumor activity of neolignans isolated from Magnolia officinalis in HeLa cancer cells.
PubMed:Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction.
PubMed:Biphenyl-type neolignans from Magnolia officinalis and their anti-inflammatory activities.
PubMed:Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice.
PubMed:Ethanol extract of Magnolia officinalis prevents lipopolysaccharide-induced memory deficiency via its antineuroinflammatory and antiamyloidogenic effects.
PubMed:A Comparison between Extract Products of Magnolia officinalis on Memory Impairment and Amyloidogenesis in a Transgenic Mouse Model of Alzheimer's Disease.
PubMed:Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis.
PubMed:Inhibitory effect of ethanol extract of Magnolia officinalis on memory impairment and amyloidogenesis in a transgenic mouse model of Alzheimer's disease via regulating β-secretase activity.
PubMed:Inhibitory effects of magnolol on voltage-gated Na+ and K+ channels of NG108-15 cells.
PubMed:Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.
PubMed:Separation and determination of honokiol and magnolol in Chinese traditional medicines by capillary electrophoresis with the application of response surface methodology and radial basis function neural network.
PubMed:Bioactive polar compounds from stem bark of Magnolia officinalis.
PubMed:Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action.
PubMed:Honokiol, a chemopreventive agent against skin cancer, induces cell cycle arrest and apoptosis in human epidermoid A431 cells.
PubMed:Honokiol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity.
PubMed:Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells.
PubMed:Pharmacokinetics, bioavailability, and tissue distribution of magnolol following single and repeated dosing of magnolol to rats.
PubMed:Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators.
PubMed:Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice.
PubMed:Protective and restorative effects of magnolol on neurotoxicity in mice with 6-hydroxydopamine-induced hemiparkinsonism.
PubMed:In vitro metabolism and disposition of honokiol in rat and human livers.
PubMed:Antimicrobial effect of Magnolia officinalis extract against Staphylococcus aureus.
PubMed:A novel aporphine alkaloid from Magnolia officinalis.
PubMed:Protective effect of a polyphenolic rich extract from Magnolia officinalis bark on influenza virus-induced pneumonia in mice.
PubMed:Magnolol suppresses metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in PC-3 human prostate carcinoma cells.
PubMed:Chemopreventive effects of honokiol on UVB-induced skin cancer development.
PubMed:[Effects of tree ages and geographic area on quality of bark of Magnolia officinalis and M. officinalis var. biloba].
PubMed:Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.
PubMed:Comparison of the volatile constituents of different parts of Cortex magnolia officinalis by GC-MS combined with chemometric resolution method.
PubMed:Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1.
PubMed:Anti-inflammatory effect of 4-O-methylhonokiol, compound isolated from Magnolia officinalis through inhibition of NF-kappaB [corrected].
PubMed:Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors.
PubMed:[Construction on ISSR fingerprint of Magnolia officinalis from Enshi in Hubei province].
PubMed:Magnolia officinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c.
PubMed:Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity.
PubMed:Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells.
PubMed:Phenolic constituents from the stem bark of Magnolia officinalis.
PubMed:[Effects of storage time on magnolol and honokiol contents in bark of Magnolia officinalis].
PubMed:[Phenols in seedling cortex of Magnolia officinalis from Enshi].
PubMed:Cytotoxic lignans from the stem bark of Magnolia officinalis.
PubMed:Effects of honokiol and magnolol on acute and inflammatory pain models in mice.
PubMed:Effects of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats.
PubMed:Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage.
PubMed:Simultaneous determination of honokiol and magnolol in Magnolia officinalis by liquid chromatography with tandem mass spectrometric detection.
PubMed:[Studies on HPLC chromatogram of phenolic constituents of Cortex Magnoliae Officinalis].
PubMed:Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures.
PubMed:Inhibitory effect of Daesungki-Tang on the invasiveness potential of hepatocellular carcinoma through inhibition of matrix metalloproteinase-2 and -9 activities.
PubMed:The inhibitory effects of aqueous extract of Magnolia officinalis on human mesangial cell proliferation by regulation of platelet-derived growth factor-BB and transforming growth factor-beta1 expression.
PubMed:Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice.
PubMed:Allylmagnolol, a novel magnolol derivative as potent antioxidant.
PubMed:[Quality evaluation and utilization of germplasm resources of Magnolia officinalis].
PubMed:[Research on DNA molecular marker of Magnolia officinalis Rehd. et Wils.--RAPD study on certified species].
PubMed:[A study on the relationship between tree age and bark quality in Magnolia officinalis].
PubMed:Synthesis and radical scavenging of novel magnolol derivatives.
PubMed:Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells.
PubMed:[A study on bark quality of Magnolia officinalis Rehd. et Wils].
PubMed:Antiallergic action of Magnolia officinalis on immediate hypersensitivity reaction.
PubMed:Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats.
PubMed:Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites.
PubMed:[Determination of magnolol and honokiol in 3 species of houpo (corter Magnoliae) of different ages by HPLC].
PubMed:Studies on inhibitors of skin tumor promotion, IX. Neolignans from Magnolia officinalis.
PubMed:Two antiplatelet agents from Magnolia officinalis.
PubMed:[Quantitative analysis of magnolol and honokiol in the bark of Magnolia officinalis Rehd et Wils and Magnolia rostrata WW Smith].
None found
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