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azadirachta indica leaf extract
extract of the leaves of azadirachta indica, miliaceae

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Name:azadirachta indica leaf extract
CAS Number: 84696-25-3
ECHA EC Number:283-644-7
FDA UNII: Search
Category:cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Neem Leaf Extract
Extrapone® Neem GW
Life Essentials - Botanicals
Odor: characteristic
Use: Extrapone® Neem GW contains an extract of neem leaves prepared in water and glycerin. Neem has been traditionally used in Ayurveda. Neem (Azadirachta Indica) leaves used for our Extrapone® are mainly collected in India. The leaves are cleaned and if necessary comminuted, dried, aqueously extracted (mazeration/percolation) and filtrated. The filtrate is concentrated by evaporation and carefully spray-dried. The concentrated neem leaf extract is prepared in a mixture of water, glycerin and preservatives and clear filtrated after an individual ripening time. 1 kg Extrapone® Neem GW contains the water soluble ingredients of approx. 100 g dried respectively of approx. 750 g fresh neem leaves. Plant material - extract (Extrapone® Neem GW) - ratio: 0.10:1 Fresh plant material - extract (Extrapone® Neem GW) - ratio: 0.75:1
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic ingredient for skin conditioning
Recommendation for azadirachta indica leaf extract usage levels up to:
 not for fragrance use.
Recommendation for azadirachta indica leaf extract flavor usage levels up to:
 not for flavor use.
Safety References:
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
azadirachta indica leaf extract
 azadirachta indica leaf extract
Pubchem (sid):135283160
Other Information:
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 neem leaf
Search Trop Picture
 antelaea azadirachta leaf extract
 extract of the leaves of azadirachta indica, miliaceae
 margosa leaf extract
 melia indica leaf extract
extrapone neem GW (Symrise)
 neem leaf extract (azadirachta indica)


PubMed:Effect of neem (Azadirachta indica A. Juss) leaf extract on resistant staphylococcus aureus biofilm formation and Schistosoma mansoni Worms.
PubMed:Multi-constituent synergism is responsible for anti-inflammatory effect of Azadirachta indica leaf extract.
PubMed:Effect of lower doses of vanadate in combination with Azadirachta indica leaf extract on hepatic and renal antioxidant enzymes in streptozotocin-induced diabetic rats.
PubMed:Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals.
PubMed:Inhibitory effect of Azadirachta indica A. juss leaf extract on the activities of alpha-amylase and alpha-glucosidase.
PubMed:Ethanolic Neem (Azadirachta indica) Leaf Extract Prevents Growth of MCF-7 and HeLa Cells and Potentiates the Therapeutic Index of Cisplatin.
PubMed:An increase of granulosa cell apoptosis mediates aqueous neem (Azadirachta indica) leaf extract-induced oocyte apoptosis in rat.
PubMed:Leaf extract of Azadirachta indica (neem): a potential antibiofilm agent for Pseudomonas aeruginosa.
PubMed:Modulatory effects of Azadirachta indica leaf extract on cutaneous and hepatic biochemical status during promotion phase of DMBA/TPA-induced skin tumorigenesis in mice.
PubMed:Effect of Neem Leaf Extract (Azadirachta indica) on c-Myc Oncogene Expression in 4T1 Breast Cancer Cells of BALB/c Mice.
PubMed:Shape-directing role of cetyltrimethylammonium bromide in the green synthesis of Ag-nanoparticles using Neem (Azadirachta indica) leaf extract.
PubMed:Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice.
PubMed:Histopathological, enzymatic, and molecular alterations induced by cigarette smoke inhalation in the pulmonary tissue of mice and its amelioration by aqueous Azadirachta indica leaf extract.
PubMed:Effects of combined leaf extract of Vernonia amygdalina and Azadirachta indica on hepatic morphology and hepatotoxicity markers in streptozotocin-induced diabetic rats.
PubMed:Attenuation of nonenzymatic glycation, hyperglycemia, and hyperlipidemia in streptozotocin-induced diabetic rats by chloroform leaf extract of Azadirachta indica.
PubMed:Synthesis of silver nanoparticles from Azadirachta indica--a most effective method for mosquito control.
PubMed:Characteristics of tomato plants treated with leaf extracts of neem (Azadirachta indica A. Juss. (L.)) and mata-raton (Gliricidia sepium (Jacquin)): a greenhouse experiment.
PubMed:Antiangiogenic Effects and Therapeutic Targets of Azadirachta indica Leaf Extract in Endothelial Cells.
PubMed:Fourier Transform Infrared Spectroscopic Studies on Modulation of N-Nitrosodiethylamine-Induced Hepatocarcinogenesis by Azadirachta indica.
PubMed:Azadirachta indica modulates electrical properties and type of cell death in NDEA-induced hepatic tumors.
PubMed:In vitro and in vivo evaluation of anti-leishmanial and immunomodulatory activity of Neem leaf extract in Leishmania donovani infection.
PubMed:Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-κB pathway.
PubMed:Antimicrobial efficacy of endodontic irrigants from Azadirachta indica: An in vitro study.
PubMed:Ameliorative effects of ethanolic leaf extract of Azadirachta indica on renal histologic alterations in streptozotocin-induced diabetic rats.
PubMed:The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats.
PubMed:Azadirachta indica acts as a pro-oxidant and modulates cell cycle associated proteins during DMBA/TPA induced skin carcinogenesis in mice.
PubMed:Azadirachta indica mitigates DMBA-induced hepatotoxicity: a biochemical and radiometric study.
PubMed:Antioxidant effect of Azadirachta indica on high fat diet induced diabetic Charles Foster rats.
PubMed:Strengthening of antioxidant defense by Azadirachta indica in alloxan-diabetic rat tissues.
PubMed:Screening and design of anti-diabetic compounds sourced from the leaves of neem (Azadirachta indica).
PubMed:Extract of Azadirachta indica (Neem) Leaf Induces Apoptosis in 4T1 Breast Cancer BALB/c Mice.
PubMed:Acaricidal activity of Cymbopogon citratus and Azadirachta indica against house dust mites.
PubMed:Azadirachta indica exhibits chemopreventive action against hepatic cancer: Studies on associated histopathological and ultrastructural changes.
PubMed:The Methanol Extract of Azadirachta indica A. Juss Leaf Protects Mice Against Lethal Endotoxemia and Sepsis.
PubMed:Medicinal properties of fractionated acetone/water neem [Azadirachta indica] leaf extract from Nigeria: a review.
PubMed:Aqueous extract of Azadirachta indica (neem) leaf induces generation of reactive oxygen species and mitochondria-mediated apoptosis in rat oocytes.
PubMed:Azadirachta indica exerts chemopreventive action against murine skin cancer: studies on histopathological, ultrastructural changes and modulation of NF-kappaB, AP-1, and STAT1.
PubMed:Chemopreventive activity of Azadirachta indica on two-stage skin carcinogenesis in murine model.
PubMed:Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: part II.
PubMed:Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems.
PubMed:Effects of Azadirachta indica on certain hematological parameters during benzo(a)pyrene induced murine forestomach tumorigenesis.
PubMed:Anxiolytic activity of Azadirachta indica leaf extract in rats.
PubMed:Effect of aqueous leaf extract of Azadirachta indica on the reproductive organs in male mice.
PubMed:Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract: part V.
PubMed:Ethanolic leaf extract of neem (Azadirachta indica) inhibits buccal pouch carcinogenesis in hamsters.
PubMed:Evaluation of antiplaque activity of Azadirachta indica leaf extract gel--a 6-week clinical study.
PubMed:Effect of Azadirachta indica hydroalcoholic leaf extract on the cardiovascular system.
PubMed:Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract. Part IV.
PubMed:Concurrent administration of aqueous Azadirachta indica (neem) leaf extract with DOCA-salt prevents the development of hypertension and accompanying electrocardiogram changes in the rat.
PubMed:Biochemical mechanism of the antimalarial activity of Azadirachta indica leaf extract.
PubMed:Mechanism of antiulcer effect of Neem (Azadirachta indica) leaf extract: effect on H+-K+-ATPase, oxidative damage and apoptosis.
PubMed:Azadirachta indica leaf extract modulates initiation phase of murine forestomach tumorigenesis.
PubMed:Impediment of diethylnitrosamine induced hepatotoxicity in male Balb/c mice by pretreatment with aqueous Azadirachta indica leaf extract.
PubMed:Spermicidal activity of Azadirachta indica (neem) leaf extract.
PubMed:Anti-cholesterolaemic activity of a fraction of azadirachta indica leaf extract on rats.
PubMed:Enhancement of immune responses to neem leaf extract (Azadirachta indica) correlates with antineoplastic activity in BALB/c-mice.
PubMed:'In vitro' antiviral activity of neem (Azadirachta indica. A. Juss) leaf extract against group B coxsackieviruses.
PubMed:Effect of azadirachta indica leaf extract on oestrous cycle of rats.
PubMed:Study on the effect of neem (Azadirachta indica A. juss) leaf extract on the growth of Aspergillus parasiticus and production of aflatoxin by it at different incubation times.
PubMed:Expression of PCNA, cytokeratin, Bcl-2 and p53 during chemoprevention of hamster buccal pouch carcinogenesis by ethanolic neem (Azadirachta indica) leaf extract.
PubMed:Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the hamster buccal pouch carcinogenesis model by modulation of Bcl-2, Bim, caspase 8 and caspase 3.
PubMed:Protective effect of fraction of azadirachta indica leaf extract on carbon tetrachloride induced hepatotoxicity.
PubMed:Anti-clastogenic activity of Azadirachta indica against benzo(a)pyrene in murine forestomach tumorigenesis bioassay.
PubMed:Pharmacological effects of Azadirachta indica (neem) leaf extract on the ECG and blood pressure of rat.
PubMed:Cytotoxicity of neem leaf extract (Azadirachta indica, Juss): an antitumour activity!
PubMed:Molecular docking based screening of neem-derived compounds with the NS1 protein of Influenza virus.
PubMed:Silver nanoparticles embedded mesoporous SiO₂ nanosphere: an effective anticandidal agent against Candida albicans 077.
PubMed:Potential of Azadirachta indica against Salmonella typhimurium-induced inflammation in BALB/c mice.
PubMed:Biogenic gold nano-triangles: cargos for anticancer drug delivery.
PubMed:Effect of neem leaf extract and neem oil on Penicillium growth, sporulation, morphology and ochratoxin A production.
PubMed:Rapid synthesis of Au, Ag, and bimetallic Au core-Ag shell nanoparticles using Neem (Azadirachta indica) leaf broth.
PubMed:Inhibition of citrinin production in Penicillium citrinum cultures by neem [Azadirachta indica A. Juss (Meliaceae)].
PubMed:Chemomodulatory effects of Azadirachta indica on the hepatic status of skin tumor bearing mice.
PubMed:A study of hypoglycaemic effects of Azadirachta indica (Neem) in normaland alloxan diabetic rabbits.
PubMed:Differently environment stable bio-silver nanoparticles: study on their optical enhancing and antibacterial properties.
PubMed:Combinatorial chemopreventive effect of Azadirachta indica and Ocimum sanctum on oxidant-antioxidant status, cell proliferation, apoptosis and angiogenesis in a rat forestomach carcinogenesis model.
PubMed:Cardioprotective effect of Azadirachta indica A. Juss. on isoprenaline induced myocardial infarction in rats.
PubMed:Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.
PubMed:Effects of neem leaf extract on production of aflatoxins and activities of fatty acid synthetase, isocitrate dehydrogenase and glutathione S-transferase in Aspergillus parasiticus.
PubMed:A comparative study of economical separation and aggregation properties of biologically capped and thiol functionalized gold nanoparticles: selecting the eco-friendly trojan horses for biological applications.
PubMed:Histochemical, ultrastructural, and biochemical evidences for Azadirachta indica-induced apoptosis in benzo(a)pyrene-induced murine forestomach tumors.
PubMed:Preventive effects of Azadirachta indica on benzo(a)pyrene-DNA adduct formation in murine forestomach and hepatic tissues.
PubMed:Inhibitory effects of Azadirachta indica on DMBA-induced skin carcinogenesis in Balb/c mice.
PubMed:Interaction between chloroquine sulphate and aqueous extract of Azadirachta indica A. Juss (Meliaceae) in rabbits.
PubMed:A study of cardiovascular effects of Azadirachta indica (neem) on isolated perfused heart preparations.
PubMed:Chemopreventive potential of neem (Azadirachta indica) on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
PubMed:Effect of Azadirachta indica on Plasmodium berghei berghei in mice.
PubMed:Azadirachta indica modulates carcinogen biotransformation and reduced glutathione at peri-initiation phase of benzo(a)pyrene induced murine forestomach tumorigenesis.
PubMed:Isolation of a snake venom phospholipase A2 (PLA2) inhibitor (AIPLAI) from leaves of Azadirachta indica (Neem): mechanism of PLA2 inhibition by AIPLAI in vitro condition.
PubMed:Neem (Azadirachta indica a. Juss) components: candidates for the control of Crinipellis perniciosa and Phytophthora ssp.
PubMed:Modulatory effects of Azadirachta indica on benzo(a)pyrene-induced forestomach tumorigenesis in mice.
PubMed:Comparison of free radical scavenging activity of Siamese neem tree (Azadirachta indica A. Juss var. siamensis Valeton) leaf extracts prepared by different methods of extraction.
PubMed:Inhibition of patulin production by Penicillium expansum cultured with neem (Azadirachta indica) leaf extracts.
PubMed:Extract of Azadirachta indica (neem) leaf induces apoptosis in rat oocytes cultured in vitro.
PubMed:Modulation of humoral and cell-mediated immune responses by Azadirachta indica (Neem) in mice.
PubMed:Hepatoprotective activity of Azadirachta indica leaves on paracetamol induced hepatic damage in rats.
PubMed:Investigation of the chemopreventive potential of neem leaf subfractions in the hamster buccal pouch model and phytochemical characterization.
PubMed:Genotoxicity of a crude leaf extract of neem in male germ cells of mice.
PubMed:Fractions of an antimalarial neem-leaf extract have activities superior to chloroquine, and are gametocytocidal.
PubMed:Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3).
PubMed:Screening of allelopathic trees for their antifungal potential against Alternaria alternata strains isolated from dying-back Eucalyptus spp.
PubMed:Comparative repellent activities of some plant extracts against Simulium damnosum complex.
PubMed:Air Pollution Tolerance Index (APTI) of some tree species growing near rail roads of Madurai, Tamil Nadu (India).
PubMed:Aqueous neem extract versus neem powder on Culex quinquefasciatus: implications for control in anthropogenic habitats.
PubMed:Nematicidal natural products from the aerial parts of Rubus niveus.
PubMed:A comparative study on the effect of plant extracts with the antibiotics on organisms of hospital origin.
PubMed:Screening of traditional antidiabetic medicinal plants of Mauritius for possible alpha-amylase inhibitory effects in vitro.
PubMed:Chemoprotective effects of ethanolic extract of neem leaf against MNNG-induced oxidative stress.
PubMed:A comparative evaluation of some blood sugar lowering agents of plant origin.
PubMed:Antifertility effects of leaf extracts of some plants in male rats.
PubMed:Folklore therapeutic indigenous plants in periodontal disorders in India (review, experimental and clinical approach).
PubMed:Antibacterial activity of some plant extracts used in folk medicine.
None found
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