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silybum marianum fruit extract
extract of the fruit of the lady's thistle, silybum marianum (l.), asteraceae

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CAS Number: 84604-20-6
ECHA EC Number:283-298-7
FDA UNII: Search
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
ECSA Chemicals
MILK THISTLE FRUIT DRY EXTRACT >25% SILBIN
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Naturex
Milk Thistle Fruit Extract
NATpharma™
Odor: characteristic
Use: Application: To relieve the symptoms associated with occasional over indulgence of food and drink such as indigestion and upset stomach.
Qingdao Dacon Trading
Milk Thistle Extract
Xi'an Greena Biotech
Milk Thistle Extract
Odor: characteristic
Use: Milk thistle is an annual or biennial herbs, native to southern Europe ,North Africa and other places.The whole plant contains flavonoids and fumaric acid.The seeds contains silybin, isosilybin, dehydrogenized silybin,silydianin, silychristin, silybin polymer and cinnamic acid, myristic acid, palmitoleic acid, arachidic acid etc. The product is tasteless, odorless, soluble in acetone, ethyl acetate, ethanol and methanol, insoluble in chloroform, do not dissolve in water. Milk thistle is widely used for the treatment of liver disease and cardiovascular disease.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 681 mg/kg
Indian Journal of Experimental Biology. Vol. 22, Pg. 487, 1984.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for silybum marianum fruit extract usage levels up to:
 not for fragrance use.
 
Recommendation for silybum marianum fruit extract flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
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EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
silybum marianum l. fruit extract
Chemidplus:0084604206
 
References:
 silybum marianum l. fruit extract
Pubchem (sid):135252480
 
Other Information:
MedlinePlusSupp:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 milk thistle
Search Trop Picture
 
Synonyms:
 extract of the fruit of the lady's thistle, silybum marianum (l.), asteraceae
lady's thistle fruit extract
ladys thistle fruit extract
milk thistle fruit extract
st. mary's thistle fruit extract
st. marys thistle fruit extract
 

Articles:

PubMed:Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).
PubMed:Absolute configuration of isosilybin A by X-ray crystallography of the heavy atom analogue 7-(4-Bromobenzoyl)isosilybin A.
PubMed:Metabolic effects of silibinin in the rat liver.
PubMed:Identification of novel pregnane X receptor activators from traditional Chinese medicines.
PubMed:Methyl jasmonate increases silymarin production in Silybum marianum (L.) Gaernt cell cultures treated with β-cyclodextrins.
PubMed:Milk thistle in liver diseases: past, present, future.
PubMed:Silymarin BIO-C, an extract from Silybum marianum fruits, induces hyperprolactinemia in intact female rats.
PubMed:Anti- and pro-mutagenic effects of silymarin in the Ames bacterial reverse mutation assay.
PubMed:Pressurized water versus ethanol as a Silybum marianum extraction solvent for inhibition of low-density lipoprotein oxidation mediated by copper and J774 macrophage cells.
PubMed:Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
PubMed:Silyamandin, a new flavonolignan isolated from milk thistle tinctures.
PubMed:[Formation of flavanolignane in the white-flowered variety (Szibilla) of Silybum marianum in relation to fruit development].
PubMed:Use of Silybum marianum fruit extract in broiler chicken nutrition: influence on performance and meat quality.
PubMed:[Study of inorganic elements in silybum marianum: distribution and extraction rate].
PubMed:Anticancer potential of silymarin: from bench to bed side.
PubMed:Structure elucidation and antioxidant activity of (-)-isosilandrin isolated from Silybum marianum L.
PubMed:Microbial transformation of silybin by Trichoderma koningii.
PubMed:A silychristin isomer and variation of flavonolignan levels in milk thistle (Silybum marianum) fruits.
PubMed:A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
PubMed:Silibinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells.
PubMed:Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans.
PubMed:Silibinin protects mice from T cell-dependent liver injury.
PubMed:Physiological responses to a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: II. alterations in thymic differentiation correlate with changes in c-myc gene expression.
PubMed:Determination of silymarine in the extract from the dried silybum marianum fruits by high performance liquid chromatography and capillary electrophoresis.
PubMed:[Tissue and suspension cultures of Silybum marianum. I. Communication: isolation and growth of tissue and suspension cultures and studies on flavonoids (author's transl)].
PubMed:The effects of silymarin on experimental phalloidine poisoning.
PubMed:[Separation of flavonoids from the fruits of St Mary's distel (Silybum marianum)].
 
Notes:
None found
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