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withania somnifera root extract
extract of the roots of the winter-cherry, withania somnifera l., solanaceae

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CAS Number: 90147-43-6
ECHA EC Number:290-434-9
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Category:cosmetic agents, dietary supplements
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Physical Properties:
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
American International Chemical, LLC.
AuNutra® Industries
Ashwagandha Extract
Ashwaganda, AF – 5404
Ashwagandha Root Withania Somnifera Root Extract
ashwagandha extract
Charkit Chemical
Grau Aromatics
Indo World Trading
Withania Somnifera Root Extract
Ashwagandha Extract
NAT healthy™
Ashwagandha Root Extract
NAT activ®
P.L. Thomas
Sabinsa Corporation
Ashwagandha - (Withania somnifera) Standardized Extract
Science and Ayurveda combined for a return to natural equilibria
Silverline Chemicals
Ashwagandha Extract (Withania somnifera) Withanolides
Synthite Industries
Ashwagandha Extract
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
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Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents, dietary supplements
Recommendation for withania somnifera root extract usage levels up to:
 not for fragrance use.
Recommendation for withania somnifera root extract flavor usage levels up to:
 not for flavor use.
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withania somnifera root extract
 withania somnifera root extract
Pubchem (sid):135338547
Other Information:
FDA Listing of Food Additive Status:View
Potential Blenders and core components note
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Potential Uses:
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Occurrence (nature, food, other):note
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 ajagandha root extract
 ashwagandha root extract
winter cherry root extract
 extract of the roots of the winter-cherry, withania somnifera l., solanaceae
indian ginseng root extract


PubMed:Protective Effects of Andrographis paniculata Extract and Pure Andrographolide Against Chronic Stress-Triggered Pathologies in Rats.
PubMed:Efficacy of Withania somnifera chemotypes NMITLI - 101R, 118R and Withaferin A against experimental visceral leishmaniasis.
PubMed:Prenatal developmental toxicity evaluation of Withania somnifera root extract in Wistar rats.
PubMed:Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats.
PubMed:Copper-stress induced alterations in protein profile and antioxidant enzymes activities in the in vitro grown Withania somnifera L.
PubMed:The effects of dietary 1, 25-dihydroxycholecalciferol and hydroalcoholic extract of Withania somnifera root on bone mineralisation, strength and histological characteristics in broiler chickens.
PubMed:Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study.
PubMed:Withania somnifera ameliorates lead-induced augmentation of adrenergic response in rat portal vein.
PubMed:Withania somnifera root extract prolongs analgesia and suppresses hyperalgesia in mice treated with morphine.
PubMed:Dynamics of withanolide biosynthesis in relation to temporal expression pattern of metabolic genes in Withania somnifera (L.) Dunal: a comparative study in two morpho-chemovariants.
PubMed:Dietary supplementation of Ashwagandha (Withania somnifera, Dunal) enhances NK cell function in ovarian tumors in the laying hen model of spontaneous ovarian cancer.
PubMed:Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats.
PubMed:Distribution of withaferin A, an anticancer potential agent, in different parts of two varieties of Withania somnifera (L.) Dunal. grown in Sri Lanka.
PubMed:Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND).
PubMed:Effect of botanical immunomodulators on human CYP3A4 inhibition: implications for concurrent use as adjuvants in cancer therapy.
PubMed:Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition.
PubMed:Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone.
PubMed:Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract.
PubMed:Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts.
PubMed:Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz.
PubMed:Effect of Withania somnifera Extracts on Some Selective Biochemical, Hematological, and Immunological Parameters in Guinea Pigs Experimental Infected with E. coli.
PubMed:De novo assembly, functional annotation and comparative analysis of Withania somnifera leaf and root transcriptomes to identify putative genes involved in the withanolides biosynthesis.
PubMed:Overexpression of WsSGTL1 gene of Withania somnifera enhances salt tolerance, heat tolerance and cold acclimation ability in transgenic Arabidopsis plants.
PubMed:Determination of withaferin A and withanolide A in mice plasma using high-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetics after oral administration of Withania somnifera aqueous extract.
PubMed:Effect of an extract of Withania somnifera root on estrogen receptor-positive mammary carcinomas.
PubMed:Withania somnifera prevents acquisition and expression of morphine-elicited conditioned place preference.
PubMed:A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.
PubMed:Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism.
PubMed:Protective effect of Withania somnifera roots extract on hematoserological profiles against lead nitrate-induced toxicity in mice.
PubMed:Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats.
PubMed:Optimization of carbon source for hairy root growth and withaferin A and withanone production in Withania somnifera.
PubMed:Structural characterization of a flavonoid glycosyltransferase from Withania somnifera.
PubMed:Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients.
PubMed:Effect of Withania somnifera supplementation on rotenone-induced oxidative damage in cerebellum and striatum of the male mice brain.
PubMed:Molecular characterization and promoter analysis of squalene epoxidase gene from Withania somnifera (L.) Dunal.
PubMed:Acute and sub-acute oral toxicity assessment of the hydroalcoholic extract of Withania somnifera roots in Wistar rats.
PubMed:Ashwagandha root in the treatment of non-classical adrenal hyperplasia.
PubMed:Qualitative and quantitative variations in withanolides and expression of some pathway genes during different stages of morphogenesis in Withania somnifera Dunal.
PubMed:Optimization of elicitation conditions with methyl jasmonate and salicylic acid to improve the productivity of withanolides in the adventitious root culture of Withania somnifera (L.) Dunal.
PubMed:Carbohydrate and elicitor enhanced withanolide (withaferin A and withanolide A) accumulation in hairy root cultures of Withania somnifera (L.).
PubMed:Functional characterization and differential expression studies of squalene synthase from Withania somnifera.
PubMed:Evaluation of antimicrobial efficacy of flavonoids of withania somnifera L.
PubMed:Oxidative stress induced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy: ameliorative effects of Withania somnifera and Withanolide A.
PubMed:The effects of phytase and root hydroalcoholic extract of Withania somnifera on productive performance and bone mineralisation of laying hens in the late phase of production.
PubMed:Influence of Withania somnifera on obsessive compulsive disorder in mice.
PubMed:Efficacy of Ashwagandha (Withania somnifera Dunal. Linn.) in the management of psychogenic erectile dysfunction.
PubMed:Prophylactic effect of Withania somnifera on inflammation in a non-autoimmune prone murine model of lupus.
PubMed:Withania somnifera chemotypes NMITLI 101R, NMITLI 118R, NMITLI 128R and withaferin A protect Mastomys coucha from Brugia malayi infection.
PubMed:Carbon sources and medium pH affects the growth of Withania somnifera (L.) Dunal adventitious roots and withanolide A production.
PubMed:Protective effect of Withania somnifera against radiation-induced hepatotoxicity in rats.
PubMed:Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.
PubMed:Comparative root protein profiles of Korean ginseng (Panax ginseng) and Indian ginseng (Withania somnifera).
PubMed:Withania somnifera chemotypes NMITLI 101R, NMITLI 118R, NMITLI 128R and Withaferin A protect Mastomys coucha from Brugia malayi infection.
PubMed:Therapeutic effect of Withania somnifera on pristane-induced model of SLE.
PubMed:Inhibition of the emergence of multi drug resistant Staphylococcus aureus by Withania somnifera root extracts.
PubMed:Enhanced in vitro regeneration and change in photosynthetic pigments, biomass and proline content in Withania somnifera L. (Dunal) induced by copper and zinc ions.
PubMed:Withania somnifera root extracts induce skin darkening in wall lizard melanophores via stimulation of cholinergic receptors.
PubMed:Application of HR-MAS NMR spectroscopy for studying chemotype variations of Withania somnifera (L.) Dunal.
PubMed:On the action and mechanism of withaferin-A from Withania somnifera, a novel and potent melanin dispersing agent in frog melanophores.
PubMed:Effect of Pueraria tuberosa tuber extract on chronic foot shock stress in Wistar rats.
PubMed:In Vitro Anticancer Activity of the Root, Stem and Leaves of Withania Somnifera against Various Human Cancer Cell Lines.
PubMed:Influence of macro elements and nitrogen source on adventitious root growth and withanolide-A production in Withania somnifera (L.) Dunal.
PubMed:An aqueous extract of Withania somnifera root inhibits amyloid β fibril formation in vitro.
PubMed:Rectal gel application of Withania somnifera root extract expounds anti-inflammatory and muco-restorative activity in TNBS-induced inflammatory bowel disease.
PubMed:Management of Parthenium hysterophorus (Asteraceae) by Withania somnifera (Solanaceae).
PubMed:Reversal of Cadmium-induced Oxidative Stress in Chicken by Herbal Adaptogens Withania Somnifera and Ocimum Sanctum.
PubMed:Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults.
PubMed:Herbicidal activity of Withania somnifera against Phalaris minor.
PubMed:In vitro protective effects of Withania somnifera (L.) dunal root extract against hydrogen peroxide and β-amyloid(1-42)-induced cytotoxicity in differentiated PC12 cells.
PubMed:Effect of Withania somnifera (L. Dunal) root as a feed additive on immunological parameters and disease resistance to Aeromonas hydrophila in Labeo rohita (Hamilton) fingerlings.
PubMed:Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha.
PubMed:Protective effect of Withania somnifera root powder on lipid peroxidation and antioxidant status in gentamicin-induced nephrotoxic rats.
PubMed:Comprehensive metabolic fingerprinting of Withania somnifera leaf and root extracts.
PubMed:Antioxidant effect of dietary supplement Withania somnifera L. reduce blood glucose levels in alloxan-induced diabetic rats.
PubMed:Effect of extract of Withania Somnifera on dehydration-induced oxidative stress-related uremia in male rats.
PubMed:Water extract of ashwagandha leaves limits proliferation and migration, and induces differentiation in glioma cells.
PubMed:Nephroprotective effect of Withania somnifera: a dose-dependent study.
PubMed:Physicochemical stability and biological activity of Withania somnifera extract under real-time and accelerated storage conditions.
PubMed:Withania somnifera Improves Semen Quality in Stress-Related Male Fertility.
PubMed:Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974.
PubMed:Generation and analysis of expressed sequence tags from leaf and root of Withania somnifera (Ashwgandha).
PubMed:Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse.
PubMed:Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington's disease.
PubMed:Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats.
PubMed:Restoration of stress-induced altered T cell function and corresponding cytokines patterns by Withanolide A.
PubMed:Neuroprotective effects of Withania somnifera dunal.: A possible mechanism.
PubMed:Genetic and withaferin A analysis of Iranian natural populations of Withania somnifera and W. coagulans by RAPD and HPTLC.
PubMed:In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes.
PubMed:Effect of Withania somnifera on Sleep-Wake Cycle in Sleep-Disturbed Rats: Possible GABAergic Mechanism.
PubMed:Establishment of Withania somnifera hairy root cultures for the production of withanolide A.
PubMed:Effect of Withania somnifera Dunal root extract against pentylenetetrazol seizure threshold in mice: possible involvement of GABAergic system.
PubMed:The relationship between chondroprotective and antiinflammatory effects of Withania somnifera root and glucosamine sulphate on human osteoarthritic cartilage in vitro.
PubMed:[Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms].
PubMed:In vitro withanolide production by Withania somnifera L. cultures.
PubMed:Transgenic mimicry of pathogen attack stimulates growth and secondary metabolite accumulation.
PubMed:Protective effect of Withania somnifera dunal root extract against protracted social isolation induced behavior in rats.
PubMed:Occurrence and distribution of hexachlorocyclohexane isomers in vegetation samples from a contaminated area.
PubMed:Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera).
PubMed:Effect of Withania somnifera root extract on haloperidol-induced catalepsy in albino mice.
PubMed:Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection.
PubMed:Protective effect of Withania somnifera Dunal on the behavioral and biochemical alterations in sleep-disturbed mice (Grid over water suspended method).
PubMed:Anti-malarial activity of withania somnifera L. Dunal extracts in mice.
PubMed:Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis.
PubMed:The neuroprotective effect of Withania somnifera root extract in MPTP-intoxicated mice: an analysis of behavioral and biochemical variables.
PubMed:Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats.
PubMed:A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice.
PubMed:Protective effect of Withania somnifera (Solanaceae) on collagen glycation and cross-linking.
PubMed:In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice.
PubMed:Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice.
PubMed:Changes in morphological phenotypes and withanolide composition of Ri-transformed roots of Withania somnifera.
PubMed:Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study.
PubMed:Antimicrobial properties of a non-toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha).
PubMed:Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity.
PubMed:Augmentation and proliferation of T lymphocytes and Th-1 cytokines by Withania somnifera in stressed mice.
PubMed:Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study.
PubMed:Hypocholesteremic and antioxidant effects of Withania somnifera (Dunal) in hypercholesteremic rats.
PubMed:Withania somnifera improves bone calcification in calcium-deficient ovariectomized rats.
PubMed:Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration.
PubMed:Effect of Withania somnifera root extract on reserpine-induced orofacial dyskinesia and cognitive dysfunction.
PubMed:Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis.
PubMed:Antiulcer and antioxidant activity of Asparagus racemosus Willd and Withania somnifera Dunal in rats.
PubMed:Enhancement of antitumor effect of paclitaxel in combination with immunomodulatory Withania somnifera on benzo(a)pyrene induced experimental lung cancer.
PubMed:Adaptogenic activity of glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaerten (part II).
PubMed:Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice.
PubMed:Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis.
PubMed:Genetically modified hairy roots of Withania somnifera Dunal: a potent source of rejuvenating principles.
PubMed:Neuritic regeneration and synaptic reconstruction induced by withanolide A.
PubMed:Withaferin A is a potent inhibitor of angiogenesis.
PubMed:Separation, identification, and quantification of selected withanolides in plant extracts of Withania somnifera by HPLC-UV(DAD)--positive ion electrospray ionisation-mass spectrometry.
PubMed:Anticarcinogenic activity of Withania somnifera Dunal against Dalton's ascitic lymphoma.
PubMed:Effect of Withania somnifera root extract on haloperidol-induced orofacial dyskinesia: possible mechanisms of action.
PubMed:Adaptogenic activity of a novel withanolide-free aqueous fraction from the roots of Withania somnifera Dun. (Part II).
PubMed:Induction of nitric oxide synthase expression by Withania somnifera in macrophages.
PubMed:Effect of Withania somnifera root extract on the sexual behaviour of male rats.
PubMed:Withania somnifera root extract prevents DMBA-induced squamous cell carcinoma of skin in Swiss albino mice.
PubMed:Neuroprotective effects of Withania somnifera Dunn. in hippocampal sub-regions of female albino rat.
PubMed:Nootropic-like effect of ashwagandha (Withania somnifera L.) in mice.
PubMed:Positive growth responses of the medicinal plants Spilanthes calva and Withania somnifera to inoculation by Piriformospora indica in a field trial.
PubMed:A biologically active constituent of withania somnifera (ashwagandha) with antistress activity.
PubMed:Adaptogenic activity of a novel, withanolide-free aqueous fraction from the roots of Withania somnifera Dun.
PubMed:Curative property of Withania somnifera Dunal root in the context of carbendazim-induced histopathological changes in the liver and kidney of rat.
PubMed:Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root.
PubMed:Effect of Withania somnifera on 20-methylcholanthrene induced fibrosarcoma.
PubMed:Immunomodulatory activity of Withania somnifera.
PubMed:Withania somnifera root extract in the regulation of lead-induced oxidative damage in male mouse.
PubMed:Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice.
PubMed:Effect of Withania somnifera on cytokine production in normal and cyclophosphamide treated mice.
PubMed:Effect of ashwagandha on lipid peroxidation in stress-induced animals.
PubMed:Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice.
PubMed:Alterations in the sensitivity of 5(th) receptor subtypes following chronic asvagandha treatment in rats.
PubMed:Inhibition of morphine tolerance and dependence by Withania somnifera in mice.
PubMed:Withanolide production by root cultures of Withania somnifera transformed with Agrobacterium rhizogenes.
PubMed:Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180.
PubMed:In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180.
PubMed:Pharmacological effects of Withania somnifera root extract on GABAA receptor complex.
PubMed:[On the trial cultivation of Withania somnifera Dunal. II. Effect of sowing season on the growth and root yield].
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