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silybum marianum extract
extract of the seeds and leaves of the lady's thistle, silybum marianum (l.), asteraceae

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Name:silybum marianum l. seeds and leaves extract
CAS Number: 84604-20-6
ECHA EC Number:283-298-7
FDA UNII: Search
Category:cosmetic agents, dietary supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 66 Milk thistle extract View - notice PDF
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Carrubba
lady's thistle extract
Grau Aromatics
ST.MARY'S THISTLE EXTRACT HS 2693 G
(hydrosoluble)
Grau Aromatics
ST.MARY'S THISTLE EXTRACT LS 4140 G
(liposoluble)
Naturex
Milk Thistle Extract
NAT healthy™
SRS Aromatics
ST.MARY'S THISTLE EXTRACT HS 2693 G
SRS Aromatics
ST.MARY'S THISTLE EXTRACT LS 4140 G
Xian Yuensun Biological Technology
Silybum Marianum Extract, Silymarin 80%, Silybin 30%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 681 mg/kg
Indian Journal of Experimental Biology. Vol. 22, Pg. 487, 1984.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents, dietary supplements
Recommendation for silybum marianum extract usage levels up to:
 not for fragrance use.
 
Recommendation for silybum marianum extract flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
silybum marianum l. seeds and leaves extract
Chemidplus:0084604206
 
References:
 silybum marianum l. seeds and leaves extract
Pubchem (sid):135252480
 
Other Information:
FDA Listing of Food Additive Status:View
MedlinePlusSupp:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 milk thistle
Search Trop Picture
 
Synonyms:
 extract of the seeds and leaves of the lady's thistle, silybum marianum (l.), asteraceae
lady's thistle extract
ladys thistle extract
st. mary's thistle extract
st. marys thistle extract
milk thistle extract (silybum marianum)
 

Articles:

PubMed:Phytotherapy And NAFLD - From Goals And Challenges To Clinical Practice.
PubMed:Effect of Silitidil, a standardized extract of milk thistle, on the serum prolactin levels in female rats.
PubMed:The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.
PubMed:Silymarin and its constituents in cardiac preconditioning.
PubMed:New therapeutic potentials of milk thistle (Silybum marianum).
PubMed:Anti-aging effects of some selected Iranian folk medicinal herbs-biochemical evidences.
PubMed:Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).
PubMed:A study on the protective effect of Silybum marianum extract on hepatic ischemia-reperfusion injury.
PubMed:Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes.
PubMed:Effects of Berberis aristata/Silybum marianum association on metabolic parameters and adipocytokines in overweight dyslipidemic patients.
PubMed:Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients.
PubMed:Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells.
PubMed:An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study.
PubMed:A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors.
PubMed:Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
PubMed:Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
PubMed:Gemmomodification: an emerging source of natural antioxidants from Silybum marianum.
PubMed:Hepatoprotective effect of silyamarin in individuals chronically exposed to hydrogen sulfide; modulating influence of TNF-α cytokine genetic polymorphism.
PubMed:Multiclass mycotoxin analysis in Silybum marianum by ultra high performance liquid chromatography-tandem mass spectrometry using a procedure based on QuEChERS and dispersive liquid-liquid microextraction.
PubMed:Enhanced bioactivity of silybin B methylation products.
PubMed:Effect of topical application of silymarin (Silybum marianum) on excision wound healing in albino rats.
PubMed:Potential antioxidant properties and hepatoprotective effects of an aqueous extract formula derived from three Chinese medicinal herbs against CCl(4)-induced liver injury in rats.
PubMed:Absolute configuration of isosilybin A by X-ray crystallography of the heavy atom analogue 7-(4-Bromobenzoyl)isosilybin A.
PubMed:Silibinin regulates matrix metalloproteinase 3 (stromelysine1) gene expression, hexoseamines and collagen production during rat skin wound healing.
PubMed:Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control.
PubMed:Silibinin modulates the NF-κb pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women.
PubMed:A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma.
PubMed:Amelioration of Ochratoxin A-induced immunotoxic effects by silymarin and Vitamin E in White Leghorn cockerels.
PubMed:Formulation of microemulsion systems for dermal delivery of silymarin.
PubMed:[Effects of the mixture of Swertia pseudochinensis Hara and Silybum marianum Gaertn extracts on CCl(4)-induced liver injury in rats with non-alcoholic fatty liver disease].
PubMed:Metabolic effects of silibinin in the rat liver.
PubMed:The effects of milk thistle on hepatic fibrosis due to methotrexate in rat.
PubMed:Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: an in vitro study.
PubMed:The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats.
PubMed:A new approach to enhance oral bioavailability of Silybum Marianum dry extract: association of mechanochemical activation and spray congealing.
PubMed:Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases.
PubMed:Effects of long-term silymarin oral supplementation on the blood biochemical profile of rainbow trout (Oncorhynchus mykiss).
PubMed:[Development of a new HPLC technique for analyzing monosaccharide composition and its application in the quality control of Silybum marianum polysaccharide].
PubMed:The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review.
PubMed:Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities.
PubMed:Evaluation of silymarin as a promising radioprotector.
PubMed:Milk thistle in liver diseases: past, present, future.
PubMed:Multiple effects of silymarin on the hepatitis C virus lifecycle.
PubMed:Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis.
PubMed:The effect of silybin on passive avoidance learning and pathological changes in hippocampal CA1 and DG regions in male Wistar rats offspring.
PubMed:Comparison of Silybum marianum (L.) Gaertn. with fluoxetine in the treatment of Obsessive-Compulsive Disorder.
PubMed:Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage.
PubMed:Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.
PubMed:Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.
PubMed:Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection.
PubMed:Optimisation of enzyme assisted extraction of silybin from the seeds of Silybum marianum by Box-Behnken experimental design.
PubMed:Silymarin BIO-C, an extract from Silybum marianum fruits, induces hyperprolactinemia in intact female rats.
PubMed:A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
PubMed:Clinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogue.
PubMed:Solid state mechanochemical activation of Silybum marianum dry extract with betacyclodextrins: Characterization and bioavailability of the coground systems.
PubMed:In vitro antioxidant activity of silymarin.
PubMed:[Influence of silymarin and doxorubicin on the myocardial function in rats].
PubMed:Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).
PubMed:Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis.
PubMed:Solid state mechanochemical simultaneous activation of the constituents of the Silybum marianum phytocomplex with crosslinked polymers.
PubMed:Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats.
PubMed:An updated systematic review with meta-analysis for the clinical evidence of silymarin.
PubMed:Some common signal transduction events are not necessary for the elicitor-induced accumulation of silymarin in cell cultures of Silybum marianum.
PubMed:In vitro evaluation and pharmacokinetics in dogs of solid dispersion pellets containing Silybum marianum extract prepared by fluid-bed coating.
PubMed:Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.
PubMed:Pressurized water versus ethanol as a Silybum marianum extraction solvent for inhibition of low-density lipoprotein oxidation mediated by copper and J774 macrophage cells.
PubMed:Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
PubMed:Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer.
PubMed:Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention.
PubMed:Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract.
PubMed:The potential of milk thistle (Silybum marianum L.), an Israeli native, as a source of edible sprouts rich in antioxidants.
PubMed:Silybin is metabolized by cytochrome P450 2C8 in vitro.
PubMed:Use of Silybum marianum fruit extract in broiler chicken nutrition: influence on performance and meat quality.
PubMed:Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin.
PubMed:Metabolomic alterations in elicitor treated Silybum marianum suspension cultures monitored by nuclear magnetic resonance spectroscopy.
PubMed:Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: a comparison using a sequential three-solvent extraction process.
PubMed:The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial.
PubMed:Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts.
PubMed:Does Silybum marianum play a role in the treatment of chronic hepatitis C?
PubMed:Evaluation of hybrid liposomes-encapsulated silymarin regarding physical stability and in vivo performance.
PubMed:[The use of flavolignans of "Silybum marianum (L.) Gaertn." to create a new fat product--fortified butter].
PubMed:A silychristin isomer and variation of flavonolignan levels in milk thistle (Silybum marianum) fruits.
PubMed:Herbal medicines for liver diseases.
PubMed:A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
PubMed:Yeast extract and methyl jasmonate-induced silymarin production in cell cultures of Silybum marianum (L.) Gaertn.
PubMed:Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks.
PubMed:Silymarin, a possible hepatoprotector in dairy cows: biochemical and histological observations.
PubMed:Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans.
PubMed:Silibinin protects mice from T cell-dependent liver injury.
PubMed:[St. Mary's Thistle: an overview].
PubMed:Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum.
PubMed:Immunostimulatory effect of Silybum Marianum (milk thistle) extract.
PubMed:Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.
PubMed:Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture.
PubMed:Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin.
PubMed:["Silymarin"--an extract from the milk thistle (Silybum marianum)--is it a drug or nutritional supplement?].
PubMed:Evaluation of the immunomodulatory effects of five herbal plants.
PubMed:Biologically active compounds of Helichrysum arenarium (L.) Moench.
PubMed:Determination of silymarine in the extract from the dried silybum marianum fruits by high performance liquid chromatography and capillary electrophoresis.
PubMed:Activities of silymarin and its flavonolignans upon low density lipoprotein oxidizability in vitro.
PubMed:A review of plants used in the treatment of liver disease: part two.
PubMed:Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.
PubMed:[High-performance liquid chromatographic separation of silymarins and their determination in a raw extract of Silybum marianum Gaertn].
 
Notes:
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