prunella vulgaris extract
extract of the whole plant, self heal, prunella vulgaris l., labiatae
None found
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Name: prunella vulgaris l. extract
CAS Number: 90105-92-3 
ECHA EC Number: 290-211-6
Category: antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
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 None found
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  750 mg/kg
Indian Journal of Experimental Biology. Vol. 7, Pg. 250, 1969.

intraperitoneal-rat LD50  300 mg/kg
Indian Journal of Experimental Biology. Vol. 16, Pg. 228, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for prunella vulgaris extract usage levels up to:
 not for fragrance use.
Recommendation for prunella vulgaris extract flavor usage levels up to:
 not for flavor use.
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Safety References:
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 prunella vulgaris l. extract
Chemidplus: 0090105923
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 prunella vulgaris l. extract
Pubchem (sid): 135289303
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 prunella vulgaris
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 austakhadus extract
 extract of the whole plant, self heal, prunella vulgaris l., labiatae
 heal all extract
 heal-all extract
 self heal extract
 self-heal extract
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PubMed: Extracts of endophytic fungus xkc-s03 from Prunella vulgaris L. spica inhibit gastric cancer in vitro and in vivo.
PubMed: Pentacyclic triterpenoids from spikes of Prunella vulgaris L. inhibit glycogen phosphorylase and improve insulin sensitivity in 3T3-L1 adipocytes.
PubMed: SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes.
PubMed: Anti-diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat-rich combination diet.
PubMed: In vitro antioxidant and anticancer effects of solvent fractions from Prunella vulgaris var. lilacina.
PubMed: Effects of Prunella vulgaris on the mice immune function.
PubMed: NF-κB-targeted anti-inflammatory activity of Prunella vulgaris var. lilacina in macrophages RAW 264.7.
PubMed: Anti-Proliferative Effect of an Aqueous Extract of Prunella vulgaris in Vascular Smooth Muscle Cells.
PubMed: The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-α-stimulated human aortic smooth muscle cells.
PubMed: Prunella vulgaris attenuates prepulse inhibition deficit and attention disruption induced by MK-801 in mice.
PubMed: The inhibitory effect of Prunella vulgaris L. on aldose reductase and protein glycation.
PubMed: Prunella vulgaris aqueous extract attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells.
PubMed: Anti-diabetic atherosclerosis effect of Prunella vulgaris in db/db mice with type 2 diabetes.
PubMed: [Experimental study of extract from Prunella vulgaris inducing B, T lymphoma cell apoptosis].
PubMed: The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases.
PubMed: A new unusual delta11(12)-oleane triterpene and anti-complementary triterpenes from Prunella vulgaris spikes.
PubMed: [Analyze on the component of rosmarinic acid in Prunella vulgaris and its effect on alpha-glycosidase activity].
PubMed: Prunella vulgaris suppresses HG-induced vascular inflammation via Nrf2/HO-1/eNOS activation.
PubMed: Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
PubMed: Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers.
PubMed: [Dynamic change of active component content in different parts of Prunella vulgaris].
PubMed: Evaluation of the anti-neuraminidase activity of the traditional Chinese medicines and determination of the anti-influenza A virus effects of the neuraminidase inhibitory TCMs in vitro and in vivo.
PubMed: Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression.
PubMed: Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L.
PubMed: Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle.
PubMed: Antioxidant activities of total phenols of Prunella vulgaris L. in vitro and in tumor-bearing mice.
PubMed: Effect of polyacetylenic acids from Prunella vulgaris on various plant pathogens.
PubMed: Identification of two polysaccharides from Prunella vulgaris L. and evaluation on their anti-lung adenocarcinoma activity.
PubMed: Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells.
PubMed: The ameliorating effect of the extract of the flower of Prunella vulgaris var. lilacina on drug-induced memory impairments in mice.
PubMed: Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression.
PubMed: Rosmarinic acid in Prunella vulgaris ethanol extract inhibits lipopolysaccharide-induced prostaglandin E2 and nitric oxide in RAW 264.7 mouse macrophages.
PubMed: Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytes.
PubMed: Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts.
PubMed: Inhibition of lentivirus replication by aqueous extracts of Prunella vulgaris.
PubMed: Triterpenoic acids of Prunella vulgaris var. lilacina and their cytotoxic activities in vitro.
PubMed: Immunostimulatory activity of aqueous extract isolated from Prunella vulgaris.
PubMed: Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models.
PubMed: Heme oxygenase-1 inducing constituent of Prunella vulgaris in HepG2 cells.
PubMed: Effects of Prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production.
PubMed: Antihyperglycemic activity of Prunella vulgaris L. in streptozotocin-induced diabetic mice.
PubMed: Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes.
PubMed: Clematis mandshurica protected to apoptosis of rat chondrocytes.
PubMed: In vitro and in vivo immunosuppressive activity of Spica Prunellae ethanol extract on the immune responses in mice.
PubMed: Biological activities of Prunella vulgaris extract.
PubMed: Inhibitory effects of rosmarinic acid on Lck SH2 domain binding to a synthetic phosphopeptide.
PubMed: Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study.
PubMed: Inhibition of immediate-type allergic reactions by Prunella vulgaris in a murine model.
PubMed: A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs.
PubMed: Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris.
PubMed: Extract of Prunella vulgaris spikes inhibits HIV replication at reverse transcription in vitro and can be absorbed from intestine in vivo.
PubMed: Anti-HIV-1 activity of herbs in Labiatae.
PubMed: [Screening test of crude drug extract on anti-HIV activity].
PubMed: Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris.
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