nerium oleander leaf extract
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Name:nerium oleander l. leaf extract
CAS Number: 84929-39-5
ECHA EC Number:284-522-6
Category:cosmetic agents
 
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Physical Properties:
Food Chemicals Codex Listed:No
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
Grau Aromatics
ROSEBAY LEAVES EXTRACT
(hydrosoluble) HS 2715 G
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Safety Information:
Oral/Parenteral Toxicity:
  oral-mouse LD50  2857 mg/kg

intraperitoneal-rat LD50  30 mg/kg

oral-chicken LDLo  18750 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA
Veterinary Bulletin Vol. 10, Pg. 624, 1940.

intramuscular-dog LDLo  25 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED CARDIAC: PULSE RATE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 189, Pg. 12, 1971.

oral-duck LDLo  1200 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA
Veterinary Bulletin Vol. 10, Pg. 624, 1940.

oral-mouse LDLo  2857 mg/kg
Journal of Toxicology and Environmental Health. Vol. 1, Pg. 939, 1976.

intraperitoneal-rat LDLo  30000 mg/kg
Journal of Toxicology and Environmental Health. Vol. 1, Pg. 939, 1976.

Dermal Toxicity:
  Not determined
Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category:cosmetic agents
Recommendation for nerium oleander leaf extract usage levels up to:
 not for fragrance use.
Recommendation for nerium oleander leaf extract flavor usage levels up to:
 not for flavor use.
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Safety References:
Daily Med:search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
National Institute of Allergy and Infectious Diseases:Data
 nerium oleander l. leaf extract
Chemidplus:0084929395
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References:
 nerium oleander l. leaf extract
Pubchem (sid):135357876
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 skin conditioning 
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Natural Occurrence in: note
 nerium oleander
GRIN Trop Picture
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Synonyms:
rose-bay extract
 oleander extract
 rosa laurel extract
 rosebay leaf extract
 rosebay leaves extract
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Articles:
PubMed:Does the Nerium oleander extract PBI-05204 have potential for pancreatic cancer therapy?
PubMed:Response to: Does the Nerium oleander extract PBI-05204 have potential for pancreatic cancer?
PubMed:Clinical and pathological features of Nerium oleander extract toxicosis in wistar rats.
PubMed:Assessment of anti-diabetic activity of an ethnopharmacological plant Nerium oleander through alloxan induced diabetes in mice.
PubMed:PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway.
PubMed:First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors.
PubMed:In vitro antifugal activity of medicinal plant extract against Fusarium oxysporum f. sp. lycopersici race 3 the causal agent of tomato wilt.
PubMed:Caffeoylquinic acids in leaves of selected Apocynaceae species: Their isolation and content.
PubMed:BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.
PubMed:Effect of Nerium oleander (N.O.) leaves extract on serum hepcidin, total iron, and infiltration of ED1 positive cells in albino rat.
PubMed:Prophylactic and therapeutic effects of garlic extract on Nerium oleander-induced arrhythmia: a new approach to antiarrhythmic therapy in an ovine model.
PubMed:Exploring a natural MDR reversal agent: potential of medicinal food supplement Nerium oleander leaf distillate.
PubMed:A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells.
PubMed:Evaluation of leaf aqueous extract and synthesized silver nanoparticles using Nerium oleander against Anopheles stephensi (Diptera: Culicidae).
PubMed:The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: discovery of an active cardiac glycoside from Urginea maritima.
PubMed:Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity.
PubMed:Hepatoprotective and antioxidant activity of methanolic extract of flowers of Nerium oleander against CCl4-induced liver injury in rats.
PubMed:Antidiabetic activity evaluation of glimepiride and Nerium oleander extract on insulin, glucose levels and some liver enzymes activities in experimental diabetic rat model.
PubMed:In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models.
PubMed:Acromyrmex octospinosus (Hymenoptera: Formicidae) management. Part 1: Effects of TRAMIL's insecticidal plant extracts.
PubMed:Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species.
PubMed:Hypolipidemic potential of flowers of Nerium oleander in high fat diet-fed Sprague Dawley rats.
PubMed:Acute cardiac toxicity of nerium oleander/indicum poisoning (kaner) poisoning.
PubMed:Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum.
PubMed:Cardioprotective effect of Nerium oleander flower against isoproterenol-induced myocardial oxidative stress in experimental rats.
PubMed:Three new cardenolides from methanol extract of stems and twigs of Nerium oleander.
PubMed:Response to 'Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee'.
PubMed:Antifungal activity of nettle (Urtica dioica L.), colocynth (Citrullus colocynthis L. Schrad), oleander (Nerium oleander L.) and konar (Ziziphus spina-christi L.) extracts on plants pathogenic fungi.
PubMed:Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee.
PubMed:Cytotoxic effects of leaf, stem and root extracts of Nerium oleander on leukemia cell lines and role of the p-glycoprotein in this effect.
PubMed:Unexpectedly dangerous escargot stew: oleandrin poisoning through the alimentary chain.
PubMed:Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities.
PubMed:Phase 1 trial of Anvirzel in patients with refractory solid tumors.
PubMed:A rare cause of complete heart block after transdermal botanical treatment for psoriasis.
PubMed:Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine.
PubMed:The cardiotonic effect of the crude ethanolic extract of Nerium oleander in the isolated guinea pig hearts.
PubMed:Toxicity of Nerium oleander leaf extract in mice.
PubMed:Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.
PubMed:Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.
PubMed:Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.
PubMed:LC/MS/MS analyses of an oleander extract for cancer treatment.
PubMed:Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.
PubMed:Bio-active cardenolides from the leaves of Nerium oleander.
PubMed:Cardenolides from the methanolic extract of Nerium oleander leaves possessing central nervous system depressant activity in mice.
PubMed:Toxic effect of ethanolic extract of Nerium oleander (Apocynaceae) leaves against different developmental stages of Muscina stabulans (Diptera-Muscidae).
PubMed:[Separation and identifying features of the cardiac aglycones and glycosides of Nerium oleander L. flowers by thin-layer chromatography].
PubMed:Glycosylation of cardenolide aglycones in the leaves of Nerium oleander.
PubMed:[Effect of several extracts derived from plants on the survival of larvae of Aedes fluviatilis (Lutz) (Diptera: Culicidae) in the laboratory].
PubMed:Oleandrin distribution in a fatality from rectal and oral Nerium oleander extract administration.
PubMed:[Diuretic effect of potable extract of Nerium oleander].
PubMed:[Cardiotonic effect of potable solution of extract of the laurel rose (Nerium oleander)].
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