nerium oleander leaf extract
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Name: nerium oleander l. leaf extract
CAS Number: 84929-39-5
ECHA EC Number: 284-522-6
Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Grau Aromatics
(hydrosoluble) HS 2715 G
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  2857 mg/kg

intraperitoneal-rat LD50  30 mg/kg

oral-chicken LDLo  18750 mg/kg
Veterinary Bulletin Vol. 10, Pg. 624, 1940.

intramuscular-dog LDLo  25 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 189, Pg. 12, 1971.

oral-duck LDLo  1200 mg/kg
Veterinary Bulletin Vol. 10, Pg. 624, 1940.

oral-mouse LDLo  2857 mg/kg
Journal of Toxicology and Environmental Health. Vol. 1, Pg. 939, 1976.

intraperitoneal-rat LDLo  30000 mg/kg
Journal of Toxicology and Environmental Health. Vol. 1, Pg. 939, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for nerium oleander leaf extract usage levels up to:
 not for fragrance use.
Recommendation for nerium oleander leaf extract flavor usage levels up to:
 not for flavor use.
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Safety References:
Daily Med: search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
 nerium oleander l. leaf extract
Chemidplus: 0084929395
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 nerium oleander l. leaf extract
Pubchem (sid): 135357876
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 skin conditioning 
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Natural Occurrence in: note
 nerium oleander
GRIN Trop Picture
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rose-bay extract
 oleander extract
 rosa laurel extract
 rosebay leaf extract
 rosebay leaves extract
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PubMed: Does the Nerium oleander extract PBI-05204 have potential for pancreatic cancer therapy?
PubMed: Response to: Does the Nerium oleander extract PBI-05204 have potential for pancreatic cancer?
PubMed: Clinical and pathological features of Nerium oleander extract toxicosis in wistar rats.
PubMed: Assessment of anti-diabetic activity of an ethnopharmacological plant Nerium oleander through alloxan induced diabetes in mice.
PubMed: PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway.
PubMed: First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors.
PubMed: In vitro antifugal activity of medicinal plant extract against Fusarium oxysporum f. sp. lycopersici race 3 the causal agent of tomato wilt.
PubMed: Caffeoylquinic acids in leaves of selected Apocynaceae species: Their isolation and content.
PubMed: BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.
PubMed: Effect of Nerium oleander (N.O.) leaves extract on serum hepcidin, total iron, and infiltration of ED1 positive cells in albino rat.
PubMed: Prophylactic and therapeutic effects of garlic extract on Nerium oleander-induced arrhythmia: a new approach to antiarrhythmic therapy in an ovine model.
PubMed: Exploring a natural MDR reversal agent: potential of medicinal food supplement Nerium oleander leaf distillate.
PubMed: A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells.
PubMed: Evaluation of leaf aqueous extract and synthesized silver nanoparticles using Nerium oleander against Anopheles stephensi (Diptera: Culicidae).
PubMed: The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: discovery of an active cardiac glycoside from Urginea maritima.
PubMed: Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity.
PubMed: Hepatoprotective and antioxidant activity of methanolic extract of flowers of Nerium oleander against CCl4-induced liver injury in rats.
PubMed: Antidiabetic activity evaluation of glimepiride and Nerium oleander extract on insulin, glucose levels and some liver enzymes activities in experimental diabetic rat model.
PubMed: In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models.
PubMed: Acromyrmex octospinosus (Hymenoptera: Formicidae) management. Part 1: Effects of TRAMIL's insecticidal plant extracts.
PubMed: Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species.
PubMed: Hypolipidemic potential of flowers of Nerium oleander in high fat diet-fed Sprague Dawley rats.
PubMed: Acute cardiac toxicity of nerium oleander/indicum poisoning (kaner) poisoning.
PubMed: Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum.
PubMed: Cardioprotective effect of Nerium oleander flower against isoproterenol-induced myocardial oxidative stress in experimental rats.
PubMed: Three new cardenolides from methanol extract of stems and twigs of Nerium oleander.
PubMed: Response to 'Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee'.
PubMed: Antifungal activity of nettle (Urtica dioica L.), colocynth (Citrullus colocynthis L. Schrad), oleander (Nerium oleander L.) and konar (Ziziphus spina-christi L.) extracts on plants pathogenic fungi.
PubMed: Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee.
PubMed: Cytotoxic effects of leaf, stem and root extracts of Nerium oleander on leukemia cell lines and role of the p-glycoprotein in this effect.
PubMed: Unexpectedly dangerous escargot stew: oleandrin poisoning through the alimentary chain.
PubMed: Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities.
PubMed: Phase 1 trial of Anvirzel in patients with refractory solid tumors.
PubMed: A rare cause of complete heart block after transdermal botanical treatment for psoriasis.
PubMed: Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine.
PubMed: The cardiotonic effect of the crude ethanolic extract of Nerium oleander in the isolated guinea pig hearts.
PubMed: Toxicity of Nerium oleander leaf extract in mice.
PubMed: Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.
PubMed: Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin.
PubMed: Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.
PubMed: LC/MS/MS analyses of an oleander extract for cancer treatment.
PubMed: Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.
PubMed: Bio-active cardenolides from the leaves of Nerium oleander.
PubMed: Cardenolides from the methanolic extract of Nerium oleander leaves possessing central nervous system depressant activity in mice.
PubMed: Toxic effect of ethanolic extract of Nerium oleander (Apocynaceae) leaves against different developmental stages of Muscina stabulans (Diptera-Muscidae).
PubMed: [Separation and identifying features of the cardiac aglycones and glycosides of Nerium oleander L. flowers by thin-layer chromatography].
PubMed: Glycosylation of cardenolide aglycones in the leaves of Nerium oleander.
PubMed: [Effect of several extracts derived from plants on the survival of larvae of Aedes fluviatilis (Lutz) (Diptera: Culicidae) in the laboratory].
PubMed: Oleandrin distribution in a fatality from rectal and oral Nerium oleander extract administration.
PubMed: [Diuretic effect of potable extract of Nerium oleander].
PubMed: [Cardiotonic effect of potable solution of extract of the laurel rose (Nerium oleander)].
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